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Diabetes is founded in approximately 2, 3 million Yankees.
The CDC estimates that an additional 84.1 million adults over the age of 18 suffer from prediabetes.
If you have diabetes, your cells cannot use insulin effectively or your pancreas cannot produce enough insulin. To keep blood glucose levels under control, the normal function of the pancreas must be altered with continuous insulin injections.
Long-acting insulin is an insulin analog that is released gradually and can be stored in the body for up to 42 hours. Blood glucose levels are lowered when short acting insulin ceases to function.
Controlling blood glucose levels can reduce the signs and symptoms of diabetes.
This is important because uncontrolled diabetes can lead to serious complications because of damage to organs and blood vessels.
For example, it can increase the risk of
- Eye damage;.
- Heart disease
- Nerve damage;.
- Kidney damage;.
- Smoothing.
This is a comparison of Tresiba and Levemir, two brands of long insulin.
Tresiba.
Tresiba (insulin degludec) is a long acting insulin used to control high blood sugar levels in adults and children over one year old with diabetes.
Its effects last up to 42 hours and can be administered at different times of the day and night.
This Ultra long-acting insulin is made by Novo Nordisk.
It cannot be administered in pill form because it is broken down in the stomach. Instead, it is injected under the skin, once a day, into the shoulder, thigh, or abdomen.
It has two strengths
- Double concentration of 200 units/ml; and
- Standard concentration of 100 units/ml.
Levemir.
Levemir (Insulin Detemir) is a long acting insulin used to treat diabetics by controlling blood sugar.
It is produced by Novo Nordisk company.
Usage
Tresiba is a basal insulin administered once daily and has an action period of 42 hours with a measured sugar reducing effect.
According to the EU-Treat study, a 16% reduction in hypovolemic incidents was observed in diabetic patients over a 180-day period 1.
In patients with diabetes 2, results showed a 67% reduction in the frequency of hypovolemic accidents over 180 days.
Levemir is used to improve glycemic control in children and adults with diabetes.
It is usually administered once a day at the same time.1 The injection works for up to 24 hours and maintains measured glucose levels in the blood.
Mechanism
Insulin degludec inhibits glucose production via the liver, primarily for fat and muscle cells, and initiates glucose absorption.
Insulin degludec helps maintain blood glucose levels within the normal spectrum by preventing the liver from producing the maximum amount of glucose and producing glucose repositioning from the bloodstream to the cells.
Side Effects.
Possible side effects of Tresiba include
- Thickening or depression of the skin in the area where the drug is administered.
- Light skin rash
- Low blood sugar levels; and
- Muscle power or la lam emotions; and
- Shortness of breath
- Numbness or tingling; and
- Increased thirst or urination.
- Chest fluttering;.
- Arrhythmia;.
- Constipation;.
- Leg cramps.
- Swelling of arms or legs;.
- Weight gain.
Possible side effects of Levemir include
- blurred vision;.
- low blood sugar levels
- muscle weakness
- Low potassium content in blood
- Nausea
- Increased heartbeat;.
- Hunger;.
- Confusion;.
- Headache;.
- Fatigue.
Dosage
Tresiba.
The initial daily need for insulin varies from 0.2 to 0.4 units of insulin per kilogram of body weight.
Dosage should be adjusted to glycemic parameters of blood glucose, metabolic needs, and motivation.
Levemir.
The initial daily total need for insulin is 1/3 of the daily total need for insulin once administered subcutaneously twice a day in divided doses.
Doses should be adjusted to blood glucose levels, metabolic needs, and motivated glycemic parameters.
Warnings and Precautions
Tresiba.
To be sure that this drug is not dangerous for you, you should tell your doctor if you are suffering from
- Diabetic ketoacidosis;.
- Kidney damage;.
- Low potassium content in the blood;.
- Liver disease.
Insulin degludec may not be suitable for people who react to metalesol, glycerol, zincacetate, or oxybenzene.
Additionally, it is not approved for use by people under 18 years of age.
Levemir.
Do not give to children under 2 years of age or if they have symptoms of low potassium content in their blood.
Drug Interactions.
Tresiba may have negative interactions with related medications.
- Aspirin;.
- Victoza (Liraglutide);.
- Furosemide (a drug used to treat water retention as a result of liver scarring, heart deficiency, or kidney disease); and
- Toleritide (dulaglutide);.
- levothyroxine;.
- metoprolol; lisinopril; and
- Lisinopril;.
- metformin; and
- Losartan.
Levemir may have negative interactions with appropriate medications.
- Victoza (Liraglutide);.
- Aspirin;.
- metoprolol; lisinopril; and
- Hydrochlorothiazide;.
- metformin; and
- zyrtec;.
- carvedilol;
- losartan; furosemide
- furosemide; lisinopril
- Lisinopril;.
- levothyroxine.
Alcohol.
Alcohol can affect blood glucose levels in diabetics.
When using these medications, it is best to avoid or completely limit alcohol consumption.
Is it safe during pregnancy and breastfeeding?
There is a lack of information regarding the safety of using Degludec insulin during pregnancy and breastfeeding.
Consult your physician to review the possible excellent properties and possible dangers before taking this insulin image.
The U.S. FDA has approved Levemir during pregnancy.
Nevertheless, there are no inexpensive data on the use of insulin-detemir by breastfeeding women.
TRESIBA vs. Levemir-Price and Efficacy
Tresiba is a very potent insulin containing degludec insulin.
It is used to improve glycemic control in diabetic patients and has a duration of action of over 42 hours.
Levemir is a long acting basal insulin containing insulin detemir. It is used to improve glycemic control in adult populations such as diabetes 2. It works within 24 hours after injection.
A 2016 study conducted at the Diabetes Research Center at Leicester Cooperative Hospital in Leicester, England, investigated the tolerability and protection in the long term of insulin detemir and insulin degludec as a basic cure for people with SEM sweet diabetes, according to the study. Insulin degludec ensures a lower risk of hypoglycemia identified at night than insulin detemir.
Another study from 2013, conducted by the Division of Diabetes, Endocrinology and Metabolism, Hyogo Medical Institute, Hyogo Medical Institute in Japan, injected insulin degludec once a day and treated with insulin degludec at lower doses and concluded that it is possible to achieve similar glycemic control with DETEMIR.
The cost of Tresiba (100 units/ml) is about US$ 514/ml. usa for 15 mL delivery, the price of Levemir (100 units/ml) is about US$ 315 for 10 mL delivery. usa for 10 ml delivery A.
Source https: // www. ncbi. nlm. nih (National Institutes of Health. Gov/PubMed/23371395 https: // www. cochrane. org/cd006383/endoc_insulin-detemir-vorsus-insulin- glargine-type 2-diabletus-mellitus-versus-glargine-type-fe-diabletus-versus-type 2-diabletus-versussins:// www. Jomrjournal. org/ article. asp ?ISSN = 2347-9906; year = 2014; what = 1; Issue = 4; spage = 209; epage = 213; aulast = bhosle https: // www. ncbi. nlm. nih. gov/PubMed/29106039 http : // care. diabetesjournals. org/content/35/12/2464
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