Usual Adult Dose for Bleeding:
Tranexamic acid
Generic name: tranexamic acid (Cyklokapron) [ tran-ex-AM-ik-AS-id ]
Brand name: Cyklokapron
Dosage form: intravenous solution (10 mg/mL-NaCl 0.7%; 100 mg/mL)
Drug class: Miscellaneous coagulation modifiers
Medically reviewed by Drugs.com on Oct 19, 2022. Written by Cerner Multum.
What is tranexamic acid (Cyklokapron)?
Tranexamic acid prevents enzymes in the body from breaking down blood clots.
Cyklokapron is used to prevent bleeding in people with hemophilia who need to have a tooth pulled. This medication is usually given just before the dental procedure, and daily for up to 8 days afterward.
Tranexamic acid may also be used for purposes not listed in this medication guide.
Warnings
You should not use Cyklokapron if you are color blind, if you have problems with the blood vessels in your eyes, or if you have ever had a stroke, blood clot, or bleeding in your brain.
Related/similar drugs
Before taking this medicine
You should not use Cyklokapron if you are allergic to tranexamic acid, or if you have:
- problems with the blood vessels in your eyes;
- color blindness (only if you are receiving the injectable form of tranexamic acid); or
- a history of stroke, blood clot, or bleeding in your brain.
Tell your doctor if you have ever had:
- kidney disease;
- a bladder or kidney infection; or
- leukemia.
Tell your doctor if you are pregnant or breastfeeding.
How is Cyklokapron given?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Cyklokapron is given as an infusion into a vein just before your tooth is pulled. You may need to keep using this medicine for up to 8 days afterward.
A healthcare provider will give your first dose and may teach you how to properly use the medication by yourself.
Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you don’t understand all instructions.
Your vision may need to be tested while you are using tranexamic acid.
Store this medicine at room temperature. Prepare an injection only when you are ready to give it.
Each vial or ampule is for one use only. Throw it away after one use, even if there is still medicine left inside.
What happens if I miss a dose?
Call your doctor for instructions if you miss a dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include headache, confusion, vision problems, vomiting, diarrhea, numbness or weakness, problems with speech or balance, feeling light-headed, or fainting.
What should I avoid while using Cyklokapron?
Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.
Cyklokapron side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Cyklokapron may cause serious side effects. Stop using Cyklokapron and call your doctor at once if you have:
- problems with your vision (including color vision);
- a light-headed feeling, like you might pass out;
- a seizure;
- painful or difficult urination, blood in your urine;
- signs of a stroke–sudden numbness or weakness (especially on one side of the body), severe headache, slurred speech, balance problems;
- signs of a blood clot in the lung–chest pain, sudden cough, wheezing, rapid breathing, coughing up blood; or
- signs of a blood clot in your leg–swelling, warmth, or redness in an arm or leg.
Common side effects include:
- nausea, vomiting, diarrhea;
- dizziness, feeling light-headed;
- mild itching or rash; or
- feeling unusually happy.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Tranexamic acid dosing information
Usual Adult Dose for Bleeding:
Initial dose: 10 mg/kg intravenously, immediately before dental extraction
Maintenance dose: 10 mg/kg intravenously three to four times daily
Duration of therapy: 2 to 8 days
Use: Short-term use in patients with hemophilia to reduce or prevent hemorrhage and reduce the need for replacement therapy during and following a tooth extraction.
Usual Adult Dose for Menstrual Disorders:
Dose: 1300 mg (two 650 mg tablets) orally three times a day (3900 mg/day) during monthly menstruation
Duration: Maximum of 5 days
Use: For the treatment of cyclic heavy menstrual bleeding
Usual Pediatric Dose for Bleeding:
Initial dose: 10 mg/kg intravenously, immediately before dental extraction
Maintenance dose: 10 mg/kg intravenously three to four times daily
Duration of therapy: 2 to 8 days
Use: Short-term use in patients with hemophilia to reduce or prevent hemorrhage and reduce the need for replacement therapy during tooth extractions.
Usual Pediatric Dose for Menstrual Disorders:
Post menarchal females:
Dose: 1300 mg (two 650 mg tablets) orally three times a day (3900 mg/day) during monthly menstruation
Duration: Maximum of 5 days
Use: For the treatment of cyclic heavy menstrual bleeding in post-menarchal females
What other drugs will affect Cyklokapron?
Tell your doctor about all your other medicines, especially:
- any type of medication to treat a bleeding episode or a blood clot; or
- factor IX complex (Bebulin, Bebulin VH, Profilnine, and others).
This list is not complete. Other drugs may affect Cyklokapron, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
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Tranexamic Acid – Uses, Side Effects, and More
This medication is used to treat heavy bleeding during your menstrual period. Tranexamic acid works by slowing the breakdown of blood clots, which helps to prevent prolonged bleeding. It belongs to a class of drugs known as antifibrinolytics.Tranexamic acid is not a hormone. It does not treat other menstrual or pre-menstrual symptoms. It does not stop your period. It is not a form of birth control and does not protect against sexually transmitted diseases.
How to use tranexamic acid oral
Read the Patient Information Leaflet if available from your pharmacist before you start taking tranexamic acid and each time you get a refill. If you have any questions regarding the information, consult your doctor or pharmacist.
Take this medication by mouth with or without food as directed by your doctor, usually 2 tablets 3 times a day (morning, afternoon, bedtime). Swallow this medication whole. Do not crush or chew. Wait until your period has started before taking your first dose. Do not take tranexamic acid for more than 5 days in a row.
Dosage is based on your medical condition and response to treatment. Do not take more than 3 doses (6 tablets) in 24 hours. Stop taking tranexamic acid and see your doctor right away if you have any eye problems or change in vision.
Tell your doctor if there is a change in your bleeding pattern or heavy bleeding persists or worsens.
Side Effects
See also How to use section.
Nausea, vomiting, diarrhea, and muscle pain may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including: eye/eyelid problems.
Although unlikely, this medication may cause serious blood clot problems. Stop taking tranexamic acid and get medical help right away if any of these very serious side effects occur: coughing up blood, fainting, chest/jaw/left arm pain, pain/swelling/warmth in the groin/calf, swelling/weakness/redness/pain in the arms/legs, signs of a stroke (such as weakness on one side of the body, trouble speaking, sudden vision changes, confusion), vision changes (such as color vision changes, decreased vision/blindness).
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Precautions
Before taking tranexamic acid, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: bleeding in the brain (subarachnoid hemorrhage), history of blood clots (such as in the legs, lung, brain, eye), certain heart diseases (irregular heartbeat, heart valve problems), blood clotting problems, kidney problems (including blood in the urine), irregular menstrual bleeding of unknown cause.
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
This medication is usually used during your menstrual period. It is unlikely to be used during pregnancy. During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
This drug passes into breast milk. Consult your doctor before breast-feeding.
Interactions
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.
Some products that may interact with this drug include: “blood thinners” (anticoagulants such as warfarin, heparin), drugs that prevent bleeding (including factor IX complex, anti-inhibitor coagulant concentrates), estrogens, hormonal birth control (such as pills, patch, ring), tibolone, tretinoin.
Check all prescription and nonprescription medicine labels carefully since many medications contain pain relievers/fever reducers (NSAIDs such as aspirin, ibuprofen, naproxen) that may increase your risk of bleeding. Low-dose aspirin should be continued if prescribed by your doctor for specific medical reasons such as heart attack or stroke prevention (usually 81-162 milligrams a day). Ask your doctor or pharmacist for more details.
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