PDL1 (Immunotherapy) Tests

A PD-L1 test Using a sample of cancer-like tumor tissue, the test measures the amount of a protein named PD-L1 that is detected in cancer cells. If you have a particular form of cancer, a PD-L1 test can indicate whether you could benefit from cancer treatment by name immunotherapy Field immunotherapy helps your personal immune system fight cancer.

PD-L1 is normally found in certain healthy cells. It acts as its own family of “brakes” and puts cells in the immune system called T cells, which can storm healthy cells in the body. If a cancer cell has lots of PD-L1, it is more likely to exclude T cells and not get a chance to attack the cancer cell.

If the cancer cells have a high PD-L1 population, immunotherapy Can you use drugs called immune checkpointimers? These drugs prevent the PD-L1 protein from slowing down the T cells. This releases T cells to fight the cancer.

Immunotherapy has the potential to stop or slow the rise of many cancers that have PD-L1. Immunotherapy has fewer side effects than chemotherapy. However, in some people it can cause serious side effects and not everyone benefits.

There are many types of PD-L1 tests . The test What your caregiver prescribes depends on

  • The type of cancer you have
  • The specific immunotherapy The medications your doctor evaluates for you.

Other names: PDL-1 for programmed death 1, PDLI, immunohistochemistry (IHC).

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What is it used for?

The PD-L1 test is used to search for PD-L1 protein in cancer cells in tumor tissue samples. The test The amount of PD-L1 in the tissue is also determined. This information helps us find if immunotherapy the drug has a chance to continue to control the cancer.

Why PD-L1 is needed test ?

If you have been diagnosed with cancer, you may need a PD-L1 test to confirm a tumor test if immunotherapy or it can help you. Almost all forms of cancer have immunotherapy PD-L1 related therapy. These cancers include

  • non-small lung cancer
  • Melanoma.
  • Hodgkin lymphoma
  • Bladder cancer
  • Kidney cancer
  • Breast cancer
  • Carcinoma of the Main and Neck (Pavement Cell Carcinoma)
  • Cancer of the digestive tract (pavement cell carcinoma)
  • Stomach cancer (adenocarcinoma)
  • Cervical cancer

What happens with PD-L1 test ?

PD-L1 tests This is done on a tissue sample of the tumor. If the tumor is removed from you, a sample will be taken for testing.

If the tumor is not removed, a biopsy can be done with you. This is a procedure in which a small amount of tissue is removed for study. If a biopsy has already been done to determine cancer, the same tissue sample can be used for the study. to test for PD-L1.

There are numerous methods to prepare a biopsy. The image of the biopsy you get will depend on the type of cancer you have and the location of the tumor. In general, you can perform a biopsy with a supportive

  • A hollow needle inserted into the skin. Visualization tests for example, ultrasound can be used to guide the needle.
    • In a narrow needle aspiration biopsy, a fairly delicate needle is used to take a cell and/or water sample.
    • A nuclear needle biopsy uses a huge needle to remove the sample.

    You will need to set up something to prepare the test ?

    Be prepared for you test Depends on how the tissue monster will be collected. Ask your own physician how to prepare the sample. test .

    There are risks. the test ?

    Risks depend on how the tissue sample is taken. In general, biopsies involve the possibility of bruising and bleeding when insulating the material. Ask your doctor to attribute the risks to you. the test you’re having.

    What do the results mean?

    Your test The results indicate whether there is enough PD-L1 protein in the tumor to benefit from a particular treatment. immunotherapy medicine. Some immunotherapy If only a small percentage of your cancer cells contain PD-L1, the drug will not help.

    If your test results show that:

    • If your tumor cells have enough PD-L1 to make use immunotherapy you can start the drug with this medication. This can be called a “positive”. test result.
    • Then the tumor cells do not have PD-L1. the immunotherapy It probably won’t help much. This could be called a “negative” test Result. Your doctor sees another way to cure the cancer.

    Your doctor may still be able to do others tests to help you choose one of the treatments that is best for you. If you have questions about your results, talk to your Internet provider.

    What do I need to know about PD-L1? test ?

    Immunotherapy is a rapidly changing area of medicine. For some immunotherapy medications are PD-L1 tests to see if they are suitable for this treatment. For other drugs, testing is recommended. However, newer investigations can be how tests used to select a treatment. Finally, contact your physician to find out how the PD-L1 test may affect your treatment plan.

    supplied by MedlinePlus from the State Medical Library.

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Alex Koliada, PhD

Alex Koliada, PhD

Alex Koliada, PhD, is a well-known doctor. He is famous for his studies of ageing, genetics and other medical conditions. He works at the Institute of Food Biotechnology and Genomics NAS of Ukraine. His scientific researches are printed by the most reputable international magazines. Some of his works are: Differences in the gut Firmicutes to Bacteroidetes ratio across age groups in healthy Ukrainian population [BiomedCentral.com]; Mating status affects Drosophila lifespan, metabolism and antioxidant system [Science Direct]; Anise Hyssop Agastache foeniculum Increases Lifespan, Stress Resistance, and Metabolism by Affecting Free Radical Processes in Drosophila [Frontiersin].
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