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If you are using one of the appropriate medications, tell your own doctor or pharmacist if it may be necessary to adjust your dosage.
OxyContin 30 mg preepo
OxyContin 5 mg, 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 60 mg, 80 mg, 120 mg tablets in long release
2. high quality and quantity composition
Each 5 mg tablet contains 4, 5 mg oxycodone in the form of 5 mg oxydone hydrochloride.
Each 10 mg tablet has 9, 0 mg oxycodone in the form of 10 mg oxycodone hydrochloride.
Each 15 mg tablet contains 13.5 mg oxycodone in the form of 15 mg oxycodone hydrochloride.
Each 20 mg tablet contains 18.0 mg oxycodone in the form of 20 mg oxycodone hydrochloride.
Each 30 mg tablet contains 27 mg of oxycodone in the form of 30 mg oxycodone hydrochloride.
Each 40 mg tablet contains 36.0 mg oxycodone in the form of 40 mg oxycodone hydrochloride.
Each 60 mg tablet contains 54 mg oxycodone in the form of 60 mg oxycodone hydrochloride.
Each 8 80 mg tablet contains 72.0 mg oxycodone in the form of 80 mg oxycodone hydrochloride.
Each 120 mg tablet has 108 mg oxycodone in the form of 120 mg oxycodone hydrochloride.
Excipients with well-known effects:
Lactose monohydrate is included.
For a complete list of excipients. 1 in section 6. 3.
3. dosage forms
Pills with long release.
The 5 mg pill is a blue, round, convex pill with the designated OC on one side and 5 tablets on the other.
10 mg pills are white, round, convex pills with the designation OC on one side and the designation 10 on the other side.
15 mg tablets are grayish, round, convex pills with the OC on one side and 15 on the other.
20 mg tablets are pink, round, convex pills with OC on one side and 20 on the other.
30 mg tablets are brownish, round, convex pills with the designated OC on one side and 30 on the other
40 mg tablets are yellowish, round, convex pills with the designated OC on one side and 40 on the other.
The 60 mg pill is a reddish, round, convex pill with the designated OC on one side and the designated 60 on the other side.
The 80 mg tablet is a greenish round convex circle with the designated OC on one side and 80 on the other.
The 120 mg pill is a purple, round, convex pill with the OC on one side and 120 on the other.
4. clinical details
4.1 Therapeutic indications
For the treatment of moderate to severe pain in patients with cancer and postoperative nuisance pain. For the cure of severe pain requiring the use of strong opioids.
4. 2 Dosage and Administration Road
Adults 18 years and older:
OxyContin tablets can be taken at 12-hour intervals. Dosage depends on the severity of the pain and previous similar analysis of the patient.
Before treatment with opioids is initiated, it can be discussed when the patient should implement strategies to complete treatment with oxycodone to minimize the risk of dependence and drug withdrawal (see Section 4).
OxyContin is not specific for use as a PRN analgesic.
As a general rule, only low effective doses for analgesia should be selected. As the severity of the pain increases, the dose of OxyContin tablets should be increased to achieve analgesic illumination, using different strengths of pills. The correct dose for an individual patient is the dose that keeps the pain under control and is fully tolerated for 12 hours. The patient should titrate until the pain is relieved. If this is not the case, side effects of the drug will not prevent this. If higher doses are needed, the structure should be obtained at 25% to 50% structure; the need to select a resource more than twice a day indicates that the dose of OxyContin tablets should be increased.
The usual initial dose for opioid patients or patients with difficult and annoying pain is 10 mg for 12 hours, not to control weak opioids. Some patients may benefit from an initial dose of 5 mg to minimize the occurrence of side effects. After this, the dose should be titrated to one analgesic per day, if necessary.
Oral morphine conversion:
Patients who received oral morphine prior to treatment with OxyContin should determine their daily dose based on the correct ratio: 10 mg of oral oxycodone corresponds to 20 mg of oral morphine. It is important to emphasize that these are instructions for the required dosage of OxyContin tablets. Due to patient-to-patient variability, all patients need to be carefully titrated to the correct dose.
Patient transfer between oral and parenteral oxycodone:
Dosages should be based on the correct proportions; 2 mg oral oxycodone corresponds to 1 mg parenteral oxycodone. It is a footnote to emphasize that these are necessary dosage instructions. Patient-to-patient variability strongly suggests that all patients must be carefully titrated to the correct dose.
Older patients:
Usually, no dose adjustment is necessary in older patients.
Controlled pharmacokinetic studies of older patients (65 years and older) show slightly decreased clearance of oxycodone compared to younger adult patients. In fact, a mature dose and dose interval is appropriate because a very favorable drug response based on age was not observed.
Pediatric Patients
OxyContin may not be used in patients younger than 18 years of age.
Patients with renal or hepatic dysfunction:
Plasma concentrations in this population may be increased. Dosage should be adjusted for the limited dosing of these patients. The appropriate starting dose should be reduced by 50% (total 10 mg oral daily dose in patients with opioid-infused vitality), and each patient should be titrated to the appropriate pain management according to medical history.
Use for harmless pain:
Opioids are not considered a part 1 therapy for non-pain without postictal sensation and are not recommended as a single treatment modality. Acquired pains that have been shown to be relieved by strong opioids include acquired osteoarthritis pain and intervertebral disc disorders. The need for continued healing of nonverbal pain should be observed at systematic intervals.
Dosage.
OxyContin tablets are intended for oral administration.
OxyContin tablets should be swallowed completely and should not be broken, chewed, or crushed.
Duration of Treatment
Oxycodone may not be used longer than necessary.
Treatment Review
When the patient no longer stubbornly demands oxycodone therapy, the dosage is intentionally decreased gradually to prevent signs of withdrawal.
4. 3 Contraindications
For hypersensitivity to oxycodone or one of the expressions referred to in Section 6.1 The patient is contraindicated in the following situations.
In history where opioids are contraindicated, opioids should not be used for hypoxia, paralytic ileum, acute abdomen, delayed gastric emptying, mammary glands, lungs, lungs, pulmonary, pulpy rudioxidxid, difficult, difficult, difficult stomach breathing respiration in the blood. Bronchial asthma, elevated carbon dioxide. Removal or destruction of objections, chronic constipation.
Patients with rare hereditary problems such as galactose intolerance, joint lactase deficiency, or glucose-galactose hyperflexia should not take this drug.
4. 4 Special Warnings and Precautions for Use
Step to oxycodone when introducing oxycodone to the elderly with caution, patients with severely impaired lung function, impaired liver or kidney function, myxoedema, hypothyroidism, Addison’s disease, toxic psychosis, benign prostatic hyperplasia, adrenocortical passion, alcoholism, double tremor, Tremeni, Tremeni, Tremeni, Double Tremeni, Tremen delirium, Glomeni, Delirium, Tremeni, Tremeni, Tremeni delirium, Tremeni delirium, Tremeni delirium, Tremeni delirium, Delirium, Delirium, Delirium, Delirium, Delirium, Delirium, Delirium, Delirium, Delirium, Delirium, delirium, delirium, delirium, delirium, delirium, delirium, delirium, delirium, delirium, delirium, delirium, delirium, delirium, delirium, delirium, delirium, delirium, delirium, delirium, delirium, delirium, delirium, delirium, delirium, delirium, delirium, delirium, delirium, delirium, delirium, delirium, delirium, delirium, delirium, delirium, delirium, delirium, delirium, delirium, delirium, delirium, delirium, delirium, delirium, delirium, delirium, delirium, delirium, delirium delirium, delirium tremens, delirium tremens, delirium tremens. Bile duct disease, pancreatitis, inflammatory conditions of the intestinal tract, hypotension, decreased blood volume that increases intracranial pressure, intracranial loss, head trauma (due to risk of increased intracranial pressure), unexplained disturbance of consciousness, sleep apnea, or in patients receiving benzodiazepines, Other, Other CNS depressants (including alcohol) or MAOIs (see Section 4. 5).
Respiratory depression is considered a major risk for opioid overdose.
Sleep-Related Respiratory Disturbances
Opioids can cause sleep-related breathing disorders, including central sleep apnea (CSA), sleep-related hypoxemia and hypoxemia. The introduction of opioids increases the risk of CSA in a dose-dependent manner. Opioids may still cause recovery from pre-existing sleep apnea (see Section 4. 8).
The concomitant use of oxycodone with sedating medications such as benzodiazepines and related drugs can lead to sedation, respiratory depression, coma, and death. Because of these risks, the combination of these sedative medications should be used only in patients for whom other treatment options are not feasible.
If it is determined that oxycodone should be used in combination with sedatives, the most effective dose should be used and the duration of treatment should be kept as short as possible (see Section 4. 2 for further recommendations regarding concomitant use).
Patients should be monitored for signs and symptoms of respiratory depression and sedation. In this connection, it is strongly recommended that patients and their caregivers be informed of these signs (see Section 4. 5).
OxyContin tablets should be used with caution in patients taking MaoI or who have received MaoI within the past 2 months.
Do not use OxyContin tablets if there is a possibility of paralytic ileus. If paralytic ileus is suspected or occurs during use, use of OxyContin tablets should be discontinued immediately.
OxyContin pills are not recommended for the first 12-24 hours before or after surgery.
As with all opioids, careful oxycodone products should be used after abdominal surgery because it is known that opioids do not respect the mobility of the intestinal tract and should not be used until the physician has assured normal function of the tract.
Patients planning to undergo supportive anesthesia procedures (surgery, plexus containment, etc.) should not ingest OxyContin tablets 12 hours prior to the procedure. If indicated after treatment with OxyContin tablets, dosage should be adjusted with fresh postoperative billing.
OxyContin 60 mg, 80 mg, and 120 mg tablets should not be used in patients who were not previously exposed to opioids. These potential tablets have every chance of causing fatal respiratory depression when administered to patients with opioid galeness.
In appropriate patients with acquired non-falsely annoying pain, opioids should be used as part of a broader treatment program that also includes other medications and treatment modalities. An important part of the evaluation of a patient with nonacquired nuisance pain is the status of dependence and substance abuse.
If treatment with opioids is appropriate for the patient, the most important task of treatment is not to minimize the opioid dose, but to achieve a dose that assures adequate pain lighting with as few side effects as possible. There should be regular contact between the physician and the patient so that dosages can be adjusted. It is strongly recommended that the physician determine the outcome of treatment according to guidelines for pain treatment. The physician and patient may agree to stop treatment if these goals are not met.
Drug Addiction, Tolerance, and Abuse Potential
Opioid user disorder (abuse and dependence)
Tolerance and physical and/or mental services may develop in repeated administration of opioids such as oxycodone. It is known that itrogenic involuntary services may occur after therapeutic use of opioids.
Updated dosing of OxyContin tablets can cause impairment in the use of opioids (older). Abuse or intentional misuse of OxyContin tablets can lead to overdose or death. The risk of old is increased in patients with a personal or family history of substance use (including alcohol consumption disorders) disorders (parents, brothers, sisters), current buyers of tobacco, or a personal history of other psychological disorders (e.g . Alcohol consumption disorders. (e.g., major depression, anxiety disorders, personality disorders).
Patients should be checked for symptoms of drug therapy (e.g., very early desire for additional medication). This includes causing simultaneous use of opioids and psychoactive substances (e.g., benzodiazepines). Patients with symptoms and signs should consider the possibility of counseling with an addiction specialist.
An extensive history of the patient should be taken to document concurrent medications, including freely available drug therapies, previous and current medical and psychiatric disorders purchased via the Internet.
Patients may find that treatment is less effective with long-term use and that the dose must be increased to achieve the same level of pain control as initially observed. Patients can still supplement treatment with extra anesthesia. These may be symptoms that the patient is developing tolerance. The patient should be aware of the dangers of developing tolerance.
Excessive or incorrect use can lead to overdose or death. It is important that patients use only the prescribed medication at the prescribed dose and not give the medication to anyone else.
Patients should be carefully monitored for symptoms of abuse, misuse, and dependence.
Clinical need for analgesic treatment should be assessed periodically.
Withdrawal Syndrome
It is helpful to discuss withdrawal strategies with the patient to stop treatment with oxycodone before opioid treatment is initiated.
Withdrawal syndromes can occur with abrupt cessation of treatment or dose reduction. If the patient no longer needs treatment, it is recommended that the dose be reduced gradually to minimize withdrawal symptoms. The highest dose reduction may take several months.
Opioid degradation syndrome is characterized by some or all of the following symptoms: agitation, watery eyes, nasal root, gaps, sweating, chills, myalgia, myopathy, kinetic pit. irritation, agitation, excitement, hyperkinesia, tremors, impotence, insomnia, anorexia, abdominal cramps, nausea, vomiting, diarrhea, increased blood pressure, frequent breathing or heart rate, and other symptoms may occur.
If a woman uses this product during pregnancy, her newborn baby is at risk for neonatal withdrawal syndrome.
Hyperalgesia can be determined as pain as a patient undergoing long-term opioid therapy. This can be clearly and anatomically distinguished from pain associated with disease progression or breakthrough pain due to opioid tolerance. Pain associated with hyperalgesia tends to be more diffuse and of lesser quality than preexisting pain. Signs of hyperalgesia may disappear when opioid doses are lowered.
OxyContin tablets should not be broken, chewed, or crushed. Breaking, chewing, or crushing OxyContin tablets can lead to rapid release and absorption of the lethal dose of oxycodone (see Section 4. 9).
Concurrent use of alcohol and OxyContin may increase the unwanted effects of OxyContin.
Abuse of oral medications in parenteral administration can be expected to produce serious unwanted effects, including local tissue necrosis, infection, pulmonary granuloma, increased risk of endocarditis, and heart valve damage.
You can see the empty matrix (pills) on the stool.
Opioids such as oxycodone hydrochloride can affect the hypothalamic hypophysis-bine-bijnieras or gonadal axis. Some configurations that can be seen are increased serum prolactin and decreased plasma cortisol and testosterone. Clinical symptoms may occur as a result of these hormonal changes.
4. 5 Interactions with other drugs and other forms of interactions
Concurrent use of Cedativa and opioids, such as benzodiazepines and similar substances, increases the risk of sedation, respiratory depression, com sleep, and death from additive CNS depressive effects. Dosage and duration of concurrent use should be limited (see Section 4. 4).Medication control roads acting on CZS include other opioids, pregabalin, anxiety, sleep, trays (including benzodiazepines), neuroleptics, antidepressants, phenothiazinen, mirelencibix, anda.
Concurrent use of oxycodone with serotonin resources such as selective serotonin reshoot inhibitors (SSRIs) or serotonin and noradrenalin reshoot inhibitors (SNRIs) can cause serotonergic toxicity. Signs of signonin toxicity may include: altered psychological status (agitation, hallucinations, com sleep), autonomic fluctuations (e.g., tachycardia, unstable blood pressure, hyperthermia), neuromuscular abnormalities (e.g., hyperventilation, lack of coordination, / or guest bowel signs, nasosis, nanoti, nanou, diarrhea). Patients using these agents should be applied with caution and may require dose reduction.
Concurrent use of oxycodone with anticholinergic agents or products with anticholinergic capabilities (tricyclic antidepressants, antihistamines, neuroleptics, myalgics, antiparkinsonian agents) may result in enhanced anticholinergic side effects. Oxycodone should be used with caution and dose reduction may be necessary in patients using these substances.
MAO inhibitors are known to interact with narcotic analgesics; MAO inhibitors can cause CZS agitation or depression in combination with hypertensive or hypotensive crisis (see section “Contraindications”). Concurrent use with or 2 months after cessation of its use with monoaminoxidase inhibitors should be avoided.
Alcohol may enhance the pharmacodynamic effects of OxyContin. Follow procedures and disregard concurrent use.
Oxycodone is metabolized primarily by CYP3A4, with involvement of CYP2D6. The potency of these metabolic routes can be inhibited or induced by a variety of drugs and nutrients taken concurrently. Oxycodone doses may need to be adjusted accordingly.
CYP3A4 inhibitors, these such as macrolide medicines (eg Clarithromycin, erythromycin and telitromycin), azol anti-immemelic agents (eg ketoconazole, voriconazole, itraconazole and posaconazol, ritonavemir, ritonirmersersersersersersersersers Ritonirir, Ritoniririr, Ritoniri Ritoninavir, Ritonirir, Ritoniririr, Ritoninavir. avxethidine Juven, Bedonine Jap), Bedonine Juse, de Debeling. as a result, oxycodone doses may need to be adjusted. Some specific examples are given below.
-Itraconazole, a potent CYP3A4 Remmer, given orally at 200 mg in the 5-day direction, multiplied by the AUC of oral oxycodone. On average, the AUCs were about 2.4 times higher (reaching 1.5 to 3.4).
-Voriconazole, a CYP3A4 lemma, was given at 200 mg twice daily in the 4-day direction (400 mg was given as the first two doses), raising the AUC of oral oxycodone. On average, AUCs were approximately 3.6-fold higher (range 2.7-5.6).
-Teritromycin, a CYP3A4 lemma, was administered orally at 800 mg in a 4-day direction and multiplied by the AUC of oral oxycodone. On average, the AUCs were approximately 1.8-fold higher (reaching 1.3 to 2.3).
– Grapefruit juice, CYP3A4 inhibitor, administered at 200 mL three times daily for 5 days, multiplied by the AUC of oral oxycodone. On average, AUCs were approximately 1.7-fold higher (reaching 1.1-2.1).
CYP3A4 inducers such as rifampicin, carbamazepine, phenytoin, and syntjanskruid have every opportunity to induce oxycodone metabolism and cause oxycodone clearance. of oxygen concentrations of rationed oxyaconcentration. Oxycodone doses may need to be adjusted. Some specific examples are given below.
-Cent John, a CYP3A4 inducer dosed at 300 mg/day for 15 days, reduced the AUC of oral oxycodone. On average, the AUC was approximately 50% lower (range 37-57%).
-Rifampicin, a CYP3A4 inducer, at a dose of 600 mg once daily, reduced the AUC from oral oxycodone. On average, the AUC was approximately 86% lower.
Drugs that inhibit CYP2D6 activity, such as paroxetine and quinidine, can cause a decrease in oxycodone statement and may lead to an increase in plasmacycid concentrations. Concurrent use of quinidine increased Oxycodon CMAX by 11%, AUC by 13%, and T½ elim by 14%. Noroxycodone was still increased (CMAX by 50%, AUC by 85%, and T½ by 42%). Pharmacodynamic effects of oxycodone were unchanged.
4.6 Fertility, Pregnancy, and Breastfeeding
OxyContin tablets are not recommended for use during pregnancy and in the family. There are limited data on the use of oxycodone in pregnant girls. Constant use during pregnancy may result in fetal pharmacological subjugation and may actually lead to neonatal withdrawal syndrome. If a pregnant girl needs to use to long-term opioids, inform the patient about the risk of neonatal opioid withdrawal syndrome and ensure that the correct treatment is available.
Infusion of the product during delivery may cause respiratory depression in the newborn, so the baby should have immediate access to an antidote.
It is not recommended to prescribe oxycodone to breastfed girls because it is distinguished in breast milk and can cause breathing problems in the baby.
4. 7 Effects on Driving Skills and Ability to Use Machines
Oxycodone can affect driving skills and ability to operate machines. Oxycodone can alter a patient’s response to varying degrees, depending on the dose and personal sensitivity. Therefore, if a patient suffers from this the patient is not allowed to drive or provide machinery.
This drug can degrade cognitive function and the patient’s ability to safely drive a vehicle. This class of drug is included in the list of substances falling within the criteria of Note 5A of the Road Traffic Act 1988. Patients are advised to be accounted for when using this medication.
– The drug may affect your driving skills.
– Do not drive until you ask what the effects of the medication are on you.
– Unless there is a defense, it is against the law to control a vehicle if there are prescribed restrictions on this drug (called a “legal defense”).
– When is this defense used
o The drug was prescribed to treat a medical or dental problem And
o You obtained it in accordance with the doctor’s instructions and the information provided on the medication.
– Note that if you cannot control a motor vehicle (i.e., it affects your ability to drive) because of the way the medication is administered, you are still prohibited from controlling a motor vehicle.
Extensive new driving information on driving after drug use in the UK can be found at https: // www. Government UK/ Drugslab – Wool.
4. 8 Unnecessary effects
Pharmacological side effects often occur with opioid agonists completely. Tolerance and submission may occur (see Section 4). Constipation can be prevented with appropriate laxatives. If nausea and vomiting are uncomfortable, oxycodone can be combined with an antimetabolite.
The following frequency categories form the basis for systematization of unwanted effects
OxyContin 30 mg preepo
Word-only versions have the option of being made available in large print, Braille, or audio compact disc. For more information, call EMC Availability on 0800 1985000. The product codes for this package leaflet are PL 16950/0098, PL 16950/0097, PL 16950/0099, PL16950/0140, PL16950/0141, PL16950/01399 PL 16950./0150, PL 16950/0123.
Totally.
OxyContin 5 mg, 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 60 mg, 80 mg, 120 mg tablets long release
Package Leaflet: User Information
OxyContin® 5 mg, 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 60 mg, 80 mg, 120 mg
This medication contains oxycodone. Oxycodone is considered an opioid that can cause obedience. Withdrawal symptoms may occur if use is stopped at certain moments.
Please read this leaflet carefully before using this medication. It contains important information. Save this leaflet well.
- Save this leaflet. You will probably have to read him again.
- If you have any questions, ask your doctor or pharmacist.
- This medicine is prescribed only for you. Do not give it to anyone else. Even if their symptoms are the same as yours, it is harmful to them.
- If you have any side effects, consult your doctor or pharmacist. This also applies to possible side effects not listed in this leaflet. See Section 4.
In this leaflet:
1. what are OxyContin pills? What are they used for? What You Should Know Before Taking OxyContin Pills 3. How to Take OxyContin Pills
1. what are oxycontin pills? What Are They Used For?
This drink is formulated to illuminate moderate to severe pain in the direction of 12 hours. It contains oxycodone, which belongs to a class of drugs called opioids and is considered a “pain reliever”. This drug is prescribed for you and may not be given to someone else. Opioids have the opportunity to cause obedience and, if stopped at some point, can result in withdrawal symptoms. Your prescribing physician should tell you the appropriate length of time to stop and when to stop so it is not dangerous to use it.
2. what you should know before taking oxycontin pills
Do not take OxyContin pills if you are
- allergies (hypersensitivity) to oxycodone or another ingredient in the pills (as described in Section 6 of this package leaflet).
- Breathing difficulties, such as severe acute obstructive pulmonary disease, severe bronchial asthma, or severe respiratory depression. Your doctor will tell you if you meet any of these criteria. Signs include. Shortness of breath, coughing, breathing slower or weaker than expected.
- The small intestine does not function properly (paralyzed ileum), the stomach pumps slower, the stomach contents are slower (delayed), or there is severe abdominal pain.
- Has heart problems after long-term non-serious illness (Cor Colmonale).
- There is increased carbon dioxide content in the blood. Signs are probably dizziness, drowsiness, fatigue, shortness of breath, headache.
- Moderate to no liver problems. If you have other long-term liver problems, you should take these medications only if recommended by your doctor.
- Persistent constipation problems.
- Has a rare hereditary case of galactose intolerance, joint lactase deficiency, or glucose-galactose hyperabsorption.
- Is under 18 years of age.
Warnings and Precautions.
Consult your own physician or pharmacist before taking these tablets.
- Whether you are someone in your family or are hooked on opioids, alcohol, prescription drugs, or illegal drugs.
- Smokers
- Have problems with mood (depression, anxiety or personality disorders) or have been treated by a psychiatrist for other psychological disorders)
- Experienced previous withdrawal symptoms such as agitation, anxiety, tremors, sweating, etc. when stopping alcohol or drugs.
- It appears that one must take more pills to obtain the same degree of pain relief. This could mean that you may become more tolerant to the results of this medication or become dependent on it. Talk to your doctor who can assess your healing and possibly change your dosage or you can switch to a different pain reliever.
- Parent or weakened.
- For example, you may have thyroid dysfunction (hypothyroidism), as a lower dose may be needed.
- myx edema (thyroid disorder with dryness, frost, edema, or swelling of the skin, which affects the person and limbs).
- Know if there is a brain injury or tumor, or if the patient has a head injury, headaches or severe headaches, or feels bedridden, as this may indicate increased pressure in the skull.
- Low blood pressure (hypotension); and
- Low blood volume (hypovolemia). This could be the result of serious external or internal bleeding, severe burns, excessive sweating, severe diarrhea or vomiting.
- Feeling quite agitated or weak.
- Has a mental disorder after using certain medications (toxic psychosis).
- Has inflammation of the pancreas (causing severe abdominal and back pain).
- Has gallbladder or bile duct problems.
- Has inflammatory bowel disease.
- （Enlarged prostate glands (in men) causing problems with urination.
- There is inadequate adrenal function (adrenal glands do not work well. This can cause impotence, weight loss, dizziness, emotions, illness, etc.) due to Addison’s disease, etc.
- Adrenal function is severely disrupted. Signs include shortness of breath and coughing.
- There is long-term pain unrelated to the cancer.
- You have an attitude of stopping breathing for short periods while you sleep, known as sleep apnea.
- Kidney and liver problems.
Regular use of this drug, especially in the long term direction, can lead to dependence and can lead to an overdose of life. If you are concerned that you are dependent on OxyContin pills, it is important to talk to your doctor. Your physician is obligated to prescribe how much you should use it and how you can place it in an unattended manner when it is appropriate to quit.
In rare cases, increasing the dosage of this medication can make you more sensitive to pain. If this happens you should talk to your doctor about your treatment.
When the use of this drug is stopped, involvement may cause withdrawal symptoms. Withdrawal symptoms may include fear, problems sleeping, irritability, agitation, excitement, a sensation of a heartbeat (kinetic pe), increased blood pressure, feelings of illness, diarrhea, loss of appetite, vibration, tremors, and sweating. Your doctor will discuss ways to lower your dosage before stopping the medication. It is important that you do not stop taking your medications all at once because you will likely experience withdrawal symptoms.
Opioids may be used only because they are prescribed. Do not give your medications to anyone else. Purchasing large or more frequent doses of opioids may increase your risk of addiction. Excessive use and abuse can lead to overdose or death.
Do not provide OxyContin pills. in the injection chamber has the ability to cause nonsense side effects such as tissue, infection, creepy inflammation, and heart damage that is likely to be fatal.
Sleep-Related Breathing Disorders
OxyContin tablets can cause sleep-related breathing problems such as sleep apnea (breathing during sleep) and sleep-related hypoxemia (low blood levels). Draws are as follows Interrupted breathing during sleep, shortness of breath that wakes you up at night, makes it difficult to fall asleep, or makes you excessively sleepy during the day. If you or someone else experiences any of these symptoms, contact your physician. Your physician may consider a dose reduction.
If you are planning an operation or have had surgery, tell your doctor at the clinic rather than using these tablets. Your doctor can adjust your dosage.
You may experience hormonal fluctuations while using these tablets. Your doctor has options to control these hormonal fluctuations.
OxyContin with other medications
Taking OxyContin pills or other medications that slow down the central nervous system can simultaneously cause slow or difficult breathing (respiratory depression), drowsiness, loss of consciousness, and death. These medications include
- Other pain for pain known as opioids (such as codeine and morphine).
- Medications for epilepsy (gabapentinoids), such as pregabalin.
- Medications for anxiety; and
- Medications used to make you sleepy (such as benzodiazepines); and
- Medications used to treat psychological or psychotic disorders (such as phenothiazines).
- Anesthetics
- muscle relaxants; and
- drugs used to treat high blood pressure.
- Images of drugs used to treat depression known as monoamine oxidase inhibitors (MAOIs), such as tranylcypromine, phenolzine, and isocarbobazide. If you are currently taking this type of medication or have taken this medication within the past two weeks, you do not need to take OxyContin tablets.
For this reason, your doctor will only give you OxyContin tablets in small doses for short periods of time if there is no other treatment available. If you or your friends, family, or parents notice that you are having difficulty breathing or are very sleepy or unconscious, you should (or should) tell your doctor immediately.
Taking OxyContin tablets along with medications used to treat depression known as selective serotonin reuptake inhibitors (SSRIs) or serotonin reuptake inhibitors (SNRIS) can cause a condition known as serotonin addiction. Signs of this include: agitation, seeing or hearing unrealistic baggage (hallucinations), loss of consciousness, fast heartbeat, changes in blood pressure, increased body temperature, muscle cramps, lack of coordination, rigidity, sensations or sickness, aches, pains, pains, sickness, or diarrhea. If you are taking SSRI or SNRI medications such as citalopram, duloxetine, escitalopram, fluoxetine, fluvaloxamine, paroxetine, sertraline, or venlafaxine, your doctor may reduce the dose of OxyContin pills.
Tell your doctor or pharmacist if you are taking, have recently taken, or may take any other medications, including nonprescription drugs.
If you are using one of the appropriate medications, tell your own doctor or pharmacist if it may be necessary to adjust your dosage.
- Types of medications used to treat depression. Amitriptyline, clomipramine, imipramine, lofepramine, and nortriptyline are known as tricyclic antidepressants.
- Allergy medications such as cetirizine, fexofenadine, and chlorphenamine.
- Medications used to treat Parkinson’s disease.
- Antibiotics such as clarithromycin, erythromycin, and telithromycin.
- Antifungal drugs such as ketoconazole, voriconazole, itraconazole, and posaconazole.
- Medicines against HIV. Well-known protease inhibitors such as voperivir, ritonavir, indinavir, nelfinavir, and saquinavir.
- Cimetidine, a drug used to treat gastric ulcers.
- Rifampicin, a drug used against tuberculosis.
- Medications for seizures, fits, and convulsions, such as carbamazepine and phenytoin.
- St. John’s wort (also known as St. John’s wort), herbal remedy used to cure depression.
- Quinidine, medicine for irregular heartbeat.
Oxycontin, a drug taken with food, drink, or alcohol.
Alcohol consumption with this medication can make you drowsy and increase the risk of serious side effects, such as superficial breathing with risk of respiratory arrest and loss of consciousness. It is not recommended to use alcohol while using OxyContin pills.
The use of grapefruit juice should be disregarded while healing with this medication.
Pregnancy and Breastfeeding
Seek advice from your own physician or pharmacist before using the medication.
Do not take OxyContin Pills if you are pregnant or think you are pregnant. Using OxyContin pills during pregnancy may cause the baby to become dependent and show withdrawal symptoms after birth.
Breastfeeding
Do not take OxyContin pills if you are breastfeeding because oxycodone leaks into breast milk and affects your baby.
Machine Driving Skills and Operation
These pills can cause a number of side effects, including drowsiness and dizziness. This may affect your ability to control a motor vehicle or operate machinery (see Section 4, “Possible Side Effects,” for a complete list of side effects). They are usually more pronounced when you first start taking the pill or when you switch to a higher dose.
- Do not drive while taking this medication until you know what it is.
- If the drug affects your driving skills, it is against the law to control a motor vehicle.
- However, it is not against the law.
- This drug was prescribed to cure a medical or dental problem.
- You took it according to the prescriber’s instructions or based on information containing the medication.
- It has not affected your ability to safely drive a vehicle.
If you doubt whether you can drive safely while using this medication, consult your physician or pharmacist.
OxyContin tablets contain lactose.
These tablets contain lactose, a type of sugar. If your doctor has told you that you do not tolerate certain sugars, consult your doctor before taking these pills.
3. how do i take oxycontin pills?
When you take these pills, take them literally, just like your doctor told you to. Your medication label will indicate the number of pills you must take and how often you must take them.
Your doctor must have discussed with you the length of time you will be prescribed OxyContin pills. He or she will organize a project to stop the healing process. This way you know how to reduce the dosage gradually and how to end the medication.
Adults (18 years and older)
The usual starting dose is 10 mg one pill every 12 hours. Your doctor will prescribe the dose needed to cure your pain anyway. If you notice that you still have pain when taking these medications, discuss it with your own physician.
Do not exceed the dosage your doctor recommends. If in doubt, you are obligated to sort this out with your doctor or pharmacist.
Take your pills completely with water. Do not crush them, do not settle them, do not chew them.
OxyContin tablets are designed to work well for 12 hours if swallowed whole. If the tablets are broken, crushed, dissolved, or chewed, the body can quickly absorb the entire 12-hour dose. This is not safe and can lead to nonsense problems such as fatal overdose.
You are obligated to take your tablets for 12 hours. For example, if you take a tablet at 8 am, you are obligated to take the next tablet at 8 pm.
You are obligated to put the pills in your mouth. Do not crush or inject the tablet. This is because it can cause serious side effects that can be fatal (see Warnings and Precautions in Section 2).
Children and adolescents under the age of 18 should not take the pills.
Patients with kidney or liver problems
Tell your doctor if you have kidney or liver problems. Depending on your condition, he or she may prescribe a lower dose.
If you are taking more OxyContin pills than you should, or if someone accidentally swallows your pills
Call your own doctor or clinic immediately. People who overdose are more likely to feel drowsy, bedridden, dizzy, or hallucinate. They may also develop breathing problems, which can be inexplicable or deadly, and need help at a clinic. If you are looking for medical assistance, make sure you take this leaflet or any other pills and show them to your doctor.
If you want to take your own OxyContin pills
If you remember in the direction of 4 hours from the moment the tablet is immediately, take the tablet immediately.
Take the right pill at the right time; if you are more than 4 hours late, call your doctor or pharmacist for advice. Do not take double doses to catch up on forgotten pills.
If you stop the Oxycontin PIL method
Do not stop this medication method at once. If you want to stop this medication, consult your doctor first. He or she will tell you how to do this. Usually by gradually lowering the dose to minimize the unfortunate consequences of withdrawal. If at some point you stop on this medication, you may suffer withdrawal symptoms such as anxiety, sleep disturbances, irritability, agitation, agitation, heart racing, elevated blood pressure, nausea, diarrhea, tremors, shaking, and sweating.
Ask your doctor or pharmacist if you have any questions about how to use this medication. 4.
4. possible side effects
As with all medications, these pills can also cause side effects, but not everyone is related to them.
All medications can cause allergic reactions, but serious allergic reactions are rare. Tell your doctor immediately if you experience sudden shortness of breath, difficulty breathing, swelling of the eyelids, swelling of the face or lips, rash, or itching, especially if it covers the entire body. These are all symptoms of a severe allergic reaction.
The most serious side effect is that you breathe slower or weaker than normal (breathing depression), which can lead to severe drowsiness and loss of consciousness. This side effect can occur in 1 in 100 people and is more common with some other medications (see Section 2, “Other Medications and OxyContin Tablets”). Tell your doctor immediately if this happens to you. You can ask your size, family member, or caregiver to watch for these signs and symptoms.
When you stop taking OxyContin tablets, you may experience withdrawal symptoms such as anxiety, trouble sleeping, irritability, agitation, anxiety, heart palpitations (racing heart), increased blood pressure, nausea, diarrhea, shaking, trembling, or sweating.
How can I recognize if I am addicted?
If you notice one of these symptoms while using OxyContin tablets, it could be a symptom that you are becoming addicted.
- You should take the medication for longer than your doctor recommends.
- You feel you must take a higher dose than recommended.
- You use the medication for reasons other than those prescribed.
- If you stop taking the medication, you feel worse, and if you take the medication again, you feel even worse.
If you notice any of these symptoms, it is important to consult your physician.
Very common side effects
(can be seen in more than 1 in 10 people)
- Constipation (your doctor may prescribe a laxative to help with this problem); and
- Emotions and nausea (this usually disappears after a few days, but your doctor can prescribe an anti-narcotic if the problem remains); and
- Drowsiness (this usually occurs when you start taking the pills or when the dose is increased, but should disappear after a few days).
- Dizziness
- Headache;.
- Itchy skin.
Frequent side effects
(This may occur in 1 in 10 patients).
- Dry mouth, decreased appetite, stomach complaints, abdominal pain or discomfort, diarrhea.
- Confusion, depression, unusual helplessness, heaviness, lack of energy, fatigue, agitation, stress, sleep problems, unusual thoughts or dreams.
- Dyspnea, creakiness, shortness of breath, decreased cough reflex.
- Skin rash;.
- Sweating.
Unusual side effects
(May occur in 1 in 100 people)
- Withdrawal symptoms (see section Stopping Medications);.
- Swallowing, burping, hiccups, wind, intestinal tract not functioning properly (ileus), stomach irritation, taste composition, or annoying taste;.
- Dizziness or feeling of spinning (vertigo), hallucinations, mood swings, uncomfortable or unpleasant mood, very happy, disorientation, restlessness, agitation, generally ill, memory loss, concert problems, sensitivity to pain or touch, tingling or numbness, seizures, attacks or convulsions, blurred or decreased vision, abnormal muscle stiffness or weakness, involuntary muscle contractions or spasms.
- Difficulty or pain in urinating, impotence, decreased sexual passion, low value of sex hormones in the blood (hypogonadism observed in blood tests).
- Fast, irregular heartbeat, heart palpitations, lightheadedness, dizziness or fainting, skin flushing.
- Dehydration, thirst, tremors, swollen hands, ankles or feet.
- Dry skin, slow peeling or blushing skin.
- Redness from the face, pupils reduced in the eyes, high fever.
- And higher doses of tablets are needed for the same degree of pain relief (tolerance).
- coli pain abdominal pain or discomfort.
- Dress up liver function tests (as indicated by blood tests).
Rare side effects
(Can reach 1 in 1, 000 people)
- Low blood pressure or weak sensation, especially when you are standing up.
- Noble, itchy skin rash (hive).
Frequency unknown.
(frequency cannot be estimated based on inexpensive data)
- Dependence and submission (“If I ask, am I dependent?” (see “I’m Dependent?”);.
- Increased feelings of pain;.
- Aggression;.
- Cavity;.
- Lack of menstruation;.
- Blockage of bile current from the liver (bile stasis). Can cause itchy skin, yellowish skin, fairly dark urine, fairly colorless stools.
- Sleep apnea (breaks in breathing during sleep);.
- Prolonged administration of OxyContin during pregnancy can lead to life-threatening withdrawal symptoms in the newborn. Drawing things to watch out for in babies include irritability, hyperactivity, abnormal sleep patterns, lots of crying, vibrations, bedness, and diarrhea.
The remains of stool tablets can be seen. This does not affect the function of the tablet.
Report Side Effects.
If side effects occur, consult your doctor, pharmacist or nurse. This applies to any possible side effects not listed in this leaflet. You can report side effects via the Yellow Card system: www. MHRA. government UK/ Yellow Card or by searching for MHRA Yellow Card on Google Play or the Apple App Store. By reporting side effects you help provide more information about the safety of this medication.
5. how do i take oxycontin pills?
Keep this medication out of sight and out of reach. Casual overdose is unsafe and fatal.
Do not use the pills after the expiration date in effect. Expiration date is the last day of the month.
Do not store pills above 25°C
Do not pick up your pills if they are broken or crushed. This is unsafe and can cause serious problems such as overdose.
Do not throw pills in the sink or through the garbage. Ask your pharmacist how to dispose of medications you no longer use. These measures will certainly help protect the surrounding environment.
6. package and other information content
What OxyContin Pills ContainOxycodone hydrochloride is considered the active ingredient. Each pill contains 5 mg, 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 60 mg, 80 mg, or 120 mg oxycodone hydrochloride.
Other ingredients are lactose monotonate, covidone, ammunition colomer, sorbin, tricetin, stearyl alcohol, toque, magnesium stearate, hypromellose (E464), titanium dioxide (E171) and macrogol.
In addition, the tablet coating contains right.
5 m g-Glossy Blue (E133)
10 m g-Hydroxypropyl Cellulose
15 m g-Iron Oxide (E172)
20 mg, 30 mg, 40 mg, 60 mg and 120 m g-PolySorbate 80 (E433) and Iron Oxide (E172)
80 m g-Hydroxypropylcellulose, iron oxide (E172) and Indigokarmijn (E132)
What OxyContin pills and package contents look like
One side of the pill has the OC and the other has the strength (5, 10, 15, 20, 30, 40, 60, 80, 80, or 120). All strengths are round, bi-component, film-coated pills.
All pills have the appropriate color film coating: 5 mg – light blue, 10 mg – broken white, 15 mg – grayish, 20 mg – iridescent, 30 mg – coffee, 40 mg – yellowish, 60 mg – 80 mg – green, 120 mg – purple.
Each box has 28 or even 56 tablets. Not all package sizes have every chance to be realized.
Marketing license holder
NAPP Pharmaceuticals Limited Cambridge Science Park Milton Road Cambridge CB4 0AB UK
Manufacturer
Bard Pharmaceuticals Limited Cambridge Science Park Milton Road Cambridge CB4 0GW UKThis package leaflet is still available in Braille or as an audio compact disc in large print.
To request a copy, call the RNIB Medicine Information Line (free of charge) on 0800 198 5000.
You will need to specify the product title and reference number. These are appropriate
Title product: OxyContin
Reference number: 16950/0123
This package leaflet was last revised in March 2022.
® OxyContin, NAPP, and the NAPP logo are considered registered trade symbols.
©2009-2022 NAPP Pharmaceuticals Limited.
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