Nicotine Lozenge Side Effects

Talk to your care team about what you can do to improve your chances of quitting.

Nicotine Lozenges: Pros and Cons

Nicotine lozenges are one form of nicotine replacement therapy that can be used to help you stop smoking over a period of time. They’re dissolving tablets you can hold in your mouth, and they come in a variety of flavors.

Nicotine replacements can ease nicotine withdrawal symptoms and allow you to control the frequency and amount of your dosage. Lozenges are dosed based on how heavy of a smoker you are. They can also be combined with the nicotine patch.

Nicotine lozenges are available in several different flavors, brands, and varieties. Nicorette and Commit are the primary brand names that offer nicotine lozenges in 2 milligram (mg) and 4 mg dosages.

The lozenges are also available as over-the-counter, generic medicines (such as the GoodSense brand) at chain drug stores across the country. Some companies like Nicorette offer regular and mini-sized lozenges, depending on your preference.

Lozenges come in 2 mg and 4 mg dosage options and are usually indicated for a use period of 8 weeks.

If you choose to use lozenges to curb your cigarette cravings, you’ll base your dosage on whether you smoke your first cigarette within half an hour of waking in the morning or after. People who begin smoking within 30 minutes of getting up generally require the 4 mg dose.

When you take your lozenge:

  • Only take one at a time.
  • Don’t eat for at least 15 minutes before use.
  • Don’t eat or drink with the lozenge in your mouth.
  • Let the lozenge sit in your mouth, moving it from side to side occasionally — don’t suck, chew, or swallow.
  • Specifically avoid consuming acidic drinks before and during lozenge use, as the acid interferes with nicotine absorption.

The lozenge should dissolve in your mouth within half an hour.

Quitting smoking can dramatically increase your overall health and quality of life — with some benefits beginning as soon as you quit.

Because smoking can adversely affect your ears, eyes, skin, and mouth, quitting could promote better hearing, sight, dermal, and oral health. Quitting can also:

  • lower your cholesterol
  • reduce your risk of heart disease and other heart issues
  • lower your risk of developing blood clots
  • reduce your risk of developing lung or oral cancers

Nicotine lozenges may be right for people who want to quit but don’t want to (or can’t) chew nicotine gum. (If you have a TMJ disorder or dentures, for example, you may not be able to chew gum.)

Lozenges are also more discreet than gum and can be more discreet than a patch. Nicorette offers a mini lozenge variety that is even easier to conceal than the standard size.

On the other hand, if you need distracting mouth movement while you get control of your cigarette craving, gum might be your best bet.

Lozenges might also be a better choice than a patch if you have a history of skin irritation to adhesive.

Nicotine patches like Nicoderm CQ deliver tiny doses of nicotine throughout the day, and they don’t require the extra maintenance of thinking about when you’re going to take your next dose.

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However, they don’t provide the same level of control over your nicotine intake that a lozenge offers. If you need to have more control over your nicotine, lozenges could be best for you.

While nicotine lozenges can help you meet your goal to quit smoking, it can be tempting to overuse or misuse them.

They’re sweet like candy, and you can use them when you need them, so it can be easy to take more than you need or more than is recommended in a 24-hour period.

People who use nicotine lozenges are meant to wean themselves off the medication within the recommended period of time. Prolonged use can raise your risk of serious side effects and withdrawal symptoms, such as:

  • anxiety
  • irritability
  • headache
  • severe nicotine cravings

Like all drugs, nicotine lozenges carry the risk of adverse side effects with use. Some common side effects include:

  • heartburn
  • indigestion
  • nausea
  • sore throat
  • hiccups

It’s also possible to overdose on nicotine when you’re using any form of nicotine replacement therapy. Overdose symptoms include:

  • severe headache
  • dizzy spells
  • passing out or severe fatigue
  • hearing loss or impairment
  • distorted or blurry vision
  • breaking out in a cold sweat
  • throwing up
  • stomach aches or stomach upset
  • mental confusion
  • drooling

If you’re addicted to the feeling of a cigarette in your mouth, you might be at risk of overusing your lozenges. In that case, you might do better chewing nicotine gum since as it gives you the mouth movements you crave in addition to a dose of nicotine.

If you know you might have issues controlling your nicotine intake via either lozenge or gum, you might want to think about using the patch instead.

Nicotine patches deliver a measured dose throughout the day, and the patches are made in gradually decreasing doses to help you wean yourself off nicotine within the recommended period.

Using nicotine lozenges can also cause serious side effects that require a visit to your doctor, including:

  • persistent throat irritation that gets increasingly worse
  • heart palpitations or irregular heartbeat (arrhythmia)
  • issues with your teeth, gums, or other tissues in your mouth (like sores)
  • interactions with other medications you may be taking
  • severe allergic reaction

You should seek your doctor’s advice before using a nicotine replacement if you:

  • have experienced cardiac issues like heart attack within the past two weeks
  • have chest pain that gets persistently worse
  • are pregnant or planning to become pregnant
  • have arrhythmia or tachycardia (rapid heart rate)
  • have experienced a stroke or ministroke within the past two weeks

With the proper combination of nicotine replacements, accountability, and support, you can overcome your smoking habit and improve your quality of life.

Become aware of the reasons why you need to quit, communicate actively and openly with your doctor, and seek a support group that will help you on your journey.

Last medically reviewed on June 7, 2018

How we reviewed this article:

Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.

  • Ebbert JO, et al. (2009). A randomized clinical trial of nicotine lozenges for smokeless tobacco use.
    ncbi.nlm.nih.gov/pmc/articles/PMC2784490/
  • How to quit smoking. (n.d.).
    lung.org/stop-smoking/i-want-to-quit/how-to-quit-smoking.html
  • Marsh HS, et al. (2005). Safety profile of a nicotine lozenge compared with that of nicotine gum in adult smokers with underlying medical conditions: A 12-week, randomized, open-label study.
    ncbi.nlm.nih.gov/pubmed/16330293
  • Nicotine lozenge. (n.d.).
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  • Nicotine lozenge. (n.d.).
    sciencedirect.com/topics/medicine-and-dentistry/nicotine-lozenge
  • Shahab L, et al. (2016). Prevalence and impact of long-term use of nicotine replacement therapy in UK Stop-Smoking services: Findings from the ELONs study.
    academic.oup.com/ntr/article/20/1/81/2629289
  • Vendrell K, et al. (2008). Chapter 17: Prevention strategies for oral cancer in Prevention in Clinical Oral Health Care. St. Louis, MS: Mosby Elsevier.
    sciencedirect.com/science/article/pii/B9780323036955500215
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Nicotine Lozenge

A nicotine lozenge helps you quit smoking by reducing your cravings for nicotine. Nicotine is the addictive substance in tobacco. A lozenge is a small tablet that you let dissolve in your mouth.

What is this medication?

NICOTINE (NIK oh teen) helps you quit smoking. It reduces cravings for nicotine, the addictive substance found in tobacco. It may also help reduce symptoms of withdrawal. It is most effective when used in combination with a stop-smoking program.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Commit, NICOrelief, Nicorette

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

  • Diabetes
  • Heart disease, angina, irregular heartbeat or previous heart attack
  • High blood pressure
  • Lung disease, including asthma
  • Overactive thyroid
  • Pheochromocytoma
  • Seizures or history of seizures
  • Stomach problems or ulcers
  • An unusual or allergic reaction to nicotine, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breast-feeding

How should I use this medication?

Place the lozenge in your mouth and allow it to slowly dissolve. Move the lozenge from one side of your mouth to the other every so often. Do not chew or swallow the lozenge. Follow the directions on the product label. Use exactly as directed. Do not use more often than directed.

This medication comes with INSTRUCTIONS FOR USE. Ask your pharmacist for directions on how to use this medication. Read the information carefully. Talk to your pharmacist or care team if you have questions.

Talk to your care team about the use of this medication in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

This does not apply.

What may interact with this medication?

  • Certain medications for lung or breathing disease, like asthma
  • Medications for blood pressure
  • Medications for depression

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

Visit your care team for regular checks on your progress.

Talk to your care team about what you can do to improve your chances of quitting.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Heart palpitations—rapid, pounding, or irregular heartbeat
  • Increase in blood pressure

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Dizziness
  • Headache
  • Heartburn
  • Hiccups
  • Irritation inside the mouth or throat
  • Trouble sleeping

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

This product may have enough nicotine in it to make children and pets sick. Keep it away from children and pets. After using, throw away as directed on the package.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from heat and light. Throw away unused medication after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

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Alex Koliada, PhD

Alex Koliada, PhD

Alex Koliada, PhD, is a well-known doctor. He is famous for his studies of ageing, genetics and other medical conditions. He works at the Institute of Food Biotechnology and Genomics NAS of Ukraine. His scientific researches are printed by the most reputable international magazines. Some of his works are: Differences in the gut Firmicutes to Bacteroidetes ratio across age groups in healthy Ukrainian population [BiomedCentral.com]; Mating status affects Drosophila lifespan, metabolism and antioxidant system [Science Direct]; Anise Hyssop Agastache foeniculum Increases Lifespan, Stress Resistance, and Metabolism by Affecting Free Radical Processes in Drosophila [Frontiersin].
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