There is a known synapse or connection between motor neurons and skeletal muscle. as neuromuscular junction There is communication between the neuron and the muscle via the neuron. Because of this communication or signal transfer, the muscle can contract or relax. This is a more widely studied synapse and is relatively easy to understand and appreciate.
Show in detail the junction what it is made of. its functions Also, some disorders associated with neuromuscular synapses. the junction .
What is a neuromuscular connection?
Motor neurons are responsible for skeletal muscle contraction by stimulating it. The gap or location between this motor neuron and the skeletal muscle cell is called a synapse. These synapses are activated by the field, especially between skeletal muscle cells and motor neurons. neuromuscular myoneural or junction Veldmio means muscle and nerve nerve. When an impulse moves between these locations, muscle contraction occurs.
In the human brain there are between 100 and 500 trillion of these connections between two nerves or nerves and glands. This memorandum discusses alone the junction .
Structure of Neuromuscular Connections
As we have read, the junction It is composed of neurons and skeletal muscle cells. Neurons are referred to in the composition of the spinal cord motoneurons. Motor neurons coming from the spinal cord enter the skeletal muscle fibers. Neuronal innervation takes place through free and delicate axonal processes. Synapses are found along these processes and are still popular as the last layer of the motor plate. structure .
The junction Synapses have three unique properties.
- There are two membranes called the presynaptic and postsynaptic membranes. There is another space between these membranes known as the synaptic fissure.
- There is a high density of small spherical blisters containing neurotransmitters.
- There is a dense synaptic membrane containing a high density of receptors that cause the binding of chemicals that pass signals from the presynaptic neuron.
Function of Neuromuscular Connections
Before looking in detail, let me remind you of it’s far-reaching effects junction It is essential to act as a bridge between neurons and muscle cells in order to pass signals.
Motor neurons – synaptic fissures – skeletal muscle cells
Calcium is preparing to invade the excitation engine, which causes exocytosis of neurotransmitters. This actually means that neurotransmitters are transported to a single, inexpensive space: the synaptic fissure. Acetylcholine is considered a neurotransmitter isolated by somatic motor neurons.
Acetylcholine sensors are located in skeletal muscle cells. This isolated acetylcholine flows through the cracks through diffusion and binds to the sensor. They look like puzzle pieces that fit together, but look like a source that opens a door. This process opens an ion channel through which sodium ions flow muscle cells. At that time, potassium ions from the muscle cells are diffusing. In particular, the number of sodium ions is greater than the number of potassium ions left by the muscle cell. As soon as the sodium ion reaches the muscle cell, it depolarizes because it is a flattering ion. As a result, the membranes of the skeletal muscle cells are raised and pulled together. This is called an action potential.
Acetylcholine does not stay in the synaptic fissure forever! the neuromuscular junction forever. This is to prevent the muscle from accelerating or maintaining itself longer than it should. An enzyme called acetylcholinesterase is considered a heavy catalyst in breaking down acetylcholine in the synaptic cleft. This leads to acetate and choline, which are returned to the synaptic fissure, where they are made again. This is called intense re-recording.
For a more accurate demonstration the junction please watch the following video
Nonvascular diseases
Some of the disorders that affect the junction Grastenia Gravis, Botulism, Eaton-Lambert Syndrome, etc. The junction Certain medications, a type of pesticide that is a poison obtained from plants and gases used in seed warfare, can still be degraded by exposure to organophosphates, considered curare. Some of these work by preventing the breakdown of acetylcholine after nerve impulses travel. Although some disorders cause muscle weakness, as explained below,
- Strictly Human Syndrome: antibodies are in the brain and spinal cord, rushing to storm nerve cells important for muscle regulation. So they become stiff.
- Isaac’s syndrome: in this case, the nerves keep sending impulses to the muscles that make them start first and eventually become aggressive. They still tend to twitch. This means that physiological exercises and routine tasks cannot be easily performed.
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