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Onychomycosis, or nail fungus infection, is caused by extra fungi climbing on the nail.
For example, nails are susceptible to infection and usually show symptoms such as thickening, discoloration, and crumbling of the edges of the nail.
Onychomycosis is very common and according to estimates, about 3 to 12% of people suffer from onychomycosis of the fingers or toes to a greater or lesser degree.
Symptoms
Onychomycosis may be present if one or some of the nails
- Slightly smelly.
- Thickened.
- Dark in color due to the accumulation of dirt under the nail.
- Distorted in shape.
- Brittle, brittle, or torn.
- White to yellowish brown discoloration.
Causes
Onychomycosis is caused primarily by dermatophytes, but less commonly by other fungi such as yeast.
Risk Factors
You are more likely to develop a nail fungus infection if you
- Wearing closed-toe shoes such as boots or tennis shoes.
- Have diabetes.
- Have a weakened immune system.
- Have a disease that causes poor circulation.
- Has fingers or toes that are wet for long periods of time.
- Is over 65 years old.
- Has damage to the skin around the nail.
- Has an injury to the nail.
- Swim in social pools.
- Has artificial nails.
Care
Common ways to treat toenail fungus include
- Nail spray cream – apply for 14 days to soften the nail so that the infection can be scraped off.
- Antifungal medications – taken once or twice a day for several months.
- Antifungal nail cream – may take up to 12 months for the infection to clear.
- Laser treatment – This is used by almost all supermen as it is painless, harmless and has few side effects on the liver.
Note – A complete nail removal procedure may be recommended in these cases.
Below is a comparison of two antifungal nail creams, Keridin and Jublia
Keridin.
This is the trade name and the alcohol solution is used to treat fungal infections of the nail layer and toenails.
The company has a product called Tavaborolol, the first antifungal drug approved by the U.S. FDA in July 2014.
Jublia.
The intensive ingredient is considered efinaconazole, a product belonging to the genus of medical drugs called antifungals.
It refers to a fungal infection of the nails caused by Trichophyton Mentagraphis or Trichophyton Rubrum.
It is applied to the affected nail like nail polish. This antifungal agent is made by Valeant Pharmaceuticals and was first approved by FDA USA in 2014.
Usage.
Both antifungal creams are used to cure nail infections, which are generally considered the result of a fungal
Mechanism
Seridin works by inhibiting fungal protein synthesis.
It inhibits cytosolic leucyltransfer RNA synthetase, an enzyme essential for the synthesis of essential fungal proteins.
Jublia works through inhibition of fungal lanosterol 14 alpha-demethylase, which is involved in the biosynthesis of key components of the fungal cell membrane.
Side Effects
Possible side effects of Keridin include.
- Ingrown Teenail;.
- Burning sensation, pain, burning hot sensation, itching, or redness at the site of use.
Possible side effects of Jublia include
- Pain, redness, inflammation, irritation with Ingrown Toenails at the site of application.
- Blisters at the site of application.
- Dermatitis;.
- Ingrown toenails.
Dosage.
Apply these fungal resistant creams once daily to affected toenails in the direction of 12 months.
Warnings and Precautions
Keridin.
Use only this antifungal cream on the nails. From nose, mouth and eyes. Do not take by mouth.
If you are allergic to any of the ingredients in this medication, you do not need to take this antifungal cream.
Additionally, it is essential to wash and dry your toenails before applying this antifungal cream.
Jublia.
The safety and efficacy of juveniles has not been determined.
Do not use this antifungal cream on your eyes, mouth, or vagina. It is specific only for the nails and surrounding skin.
Avoid the use of nail polish, pedicure, and nail cosmetics when using this antifungal cream.
Interactions with Medications
It is unlikely that these antifungal creams have interactions with other products.
Alcohol.
There are no popular interactions between alcohol consumption and these antifungal creams.
Are they safe during pregnancy or breastfeeding?
You must tell your doctor if you are pregnant or breastfeeding before using these antifungal creams. This is because no studies have been done on the use of these antifungals during breastfeeding or pregnancy.
Keridin vs. Jublia – Price & amp; amp; Efficacy
Keridin (Tavaborolol) important solution is an antifungal agent regarding oxaborolol and is prescribed for the cure of fungi (onychomycosis) by Trichophyton mentiglaphis and Trichophyton rubrum.
Due to the presence of fairly small drills in the structures, this antifungal agent has a strong resistant effect.
Jublia (efinaconazole) an important solution is azool antifungal prescribed for the cure of The terminal fungus (onychomycosis) by Trichopyton Mentagraphis and Trichophyton Rubrum.
According to this study, efinaconazole (Jublia) and tababorole (Keridin) cured fungal nail infections in 6.5 to 17.8% of patients.
The price of Jublia is US $606 per 4 mL; the price of Keridin is US $639 per 4 mL.
Alternatives to Jublia and Seridin
The best options for these antifungal creams are
- Ciclopirox (Penlac 8%) nail polish – tackles all kinds of metabolic processes in fungal cells.
- Amorolfin (5%) Nail Polish – This is an important anti-mycotic explorer with fungal killing effects.
Prevention of fungal infections of the nails
Use support to reduce the risk of onychomycosis.
- Treat athlete’s feet immediately to prevent spread to the nails.
- Keep feet and hands controlled and dry.
- Replace old shoes that may be infected with fungus.
- Use special shower shoes to protect their feet and prevent walking barefoot in public showers, pools, and locker rooms.
- Make sure towels are always washed.
- Do not share socks or clean towels with others.
- Scissors and machines are not shared with others.
- Toenails are shortened and kept short.
- To allow feet to “breathe,” wear cotton socks and shoes that are fully seated and made of natural materials.
Source http: // www. jabfm. org/content/24/1/69. completely https: // smhs. gwu. edu/Newss/Research-Ide-Ide-Cost-Option-Tail-Fungus-Nanotechnology https : // www. NCBI. NLM. NIH (National Institutes of Health. Gov/PubMed/24850511 https: // www. NCBI. NLM. NIH (National Institutes of Health. Gov/PMC/ Article/PMC459619/
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