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Digoxin is a steroidal glycoside prepared from dried foxglove leaves and used in small doses as a cardiac catalyst to improve cardiac power and efficiency or to control heart rate rate and rhythm. Digoxin initiates myocardium and improves blood flow. Digoxin is still used to treat non-serious or moderate congestive heart failure, atrial fibrillation, abnormal heart rhythms, and men to increase myocardial contractility.
Digoxin’s mechanism of action
All of Digoxin’s actions Working with the Na-K ATPase, it is responsible for stabilizing and maintaining the chemical gradients of sodium and potassium ions in the plasma membrane. Sodium String Pump the active transport of potassium ions through organic membranes. This K-PAM is responsible for maintaining the intracellular environment throughout the body through the movement of potassium ions through the cell and sodium ions through inhibition of the ATPase Na-K. Digoxin. mechanism of action includes:
- In the myocardial and guiding systems, digoxin causes an increase in intracellular calcium availability along with an increase in automaticity, causing an internal increase, and a decrease in guiding velocity.
- As a result, digoxin affects the sinus and atrioventricular nodes while indirectly causing parasympathetic stimulation of the autonomic nervous system.
- Digoxin makes blood vessels more sensitive to exogenous or endogenous catecholamines by reducing the reversible catch of catecholamines at nerve endings.
- As a result, digoxin increases the potency of the neck nerves, improving sympathetic withdrawal with each increase in mean arterial pressure and susceptibility to pressure-pressure infection.
- At high concentrations, digoxin increases both cardiac and peripheral sympathetic outflow and sympathetic outflow from the central nervous system.
- At high concentrations, digoxinquin may affect serum potassium concentrations and increase intracellular potassium effects LUX.
The cardiological consequences of these indirect and direct effects are delayed heart rate, decreased conductive velocity by the AV node, increased power and rate of systolic contraction of the myocardium, or a flattering disabling effect. action Reduce the degree of activation of the sympathetic nervous system, the renin-angiotensin system, and the deactivating effects of neurohormones.
How to take digoxin safely
Be knowledgeable about digoxin. mechanism of action Is it still of fundamental importance to know how to use the drug in the right way for best results?
Before taking it
Before taking digoxin, you should tell your doctor if you have ever had an allergic reaction to digoxin or any other medication. Also tell your doctor if you are planning to have a baby or are expecting a baby, as it is not clear whether the drug will affect the fetus.
Make sure your doctor is aware of the following health conditions
- Critical cardiac conditions such as AV block unless Pacemaker is used or dysfunction of the sinuses (sinus disease).
- Recent cardiac arrest
- Fast heartbeats such as supraventricular tachycardia, Wolff-Parkinson-White syndrome, or chest fibrillation.
- Thyroid disease if present.
- If blood tests show low potassium, calcium, or magnesium content, this can lead to electrolyte imbalance.
- If you have recently become ill or suffer from malnutrition as a result of vomiting or diarrhea.
- If you have kidney disease.
- If you are using steroids or taking diuretics (water pills)
- If you are breastfeeding your baby
How.
- Take digoxin orally with or without food as directed by your doctor. However, your body may not absorb this product completely, as it may with fiber-rich foods or when used in combination with other medications. For best results, it is recommended to take digoxin at least 2 hours before or 2 hours after a meal.
- If using certain medications such as Kyrillium, Cholestypol, or Cholestyramine, one should wait no more than 2 hours from the digoxin route. Other medications such as gastric acid inhibitors, magnesium milk, kaoliene – sulfasalazine, aminosalicylic acid, or metoclopramide should be taken as soon as possible after the digoxide dose.
- The dosage of this medication is based on your health, weight, age, clinical examination, and response to treatment. When using digoxin in the water form, the correct dosage is critical. Therefore, measure the dosage carefully with the dropper supplied by the manufacturer and do not use a household ribbon.
- Consult your physician before stopping the use of this medication, as digoxin may be useful for continued use and your situation may worsen.
Possible side effects of digoxin
Through Digoxin mechanism of action situation can be controlled. However, it can still cause a number of side effects
- Headache, dizziness, loss of appetite, drowsiness, nausea, and diarrhea may occur. If one of these effects persists or worsens, tell your doctor or pharmacist immediately.
- Tell your doctor immediately if any of these almost impossible but serious side effects occur, such as blurred, yellowish or greenish vision, mental/mood configurations, impotence, or visual configurations such as gynecological (enlarged breasts).
- Digoxin is used to treat certain forms of irregular heartbeats, but may cause other forms of irregular heartbeats. If you notice an abnormally fast, slow, or irregular heartbeat, tell your doctor immediately.
- Very serious allergic reactions to digoxin are rare. Nevertheless, if you notice signs of a severe allergic reaction, such as itching or swelling of the face, tongue, throat, or breathing problems, skin rash, or significant dizziness, find medical help immediately.
This is not an absolute list of possible side effects. If you notice any of the other effects listed above, contact your physician or pharmacist.
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