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The liver These cells produce bile that flows through ducts in the gallbladder. the liver It then reaches the gallbladder. Bile plays an important role in the faithful digestion of fats and fat-soluble vitamins. In some people, the liver unable to produce bile, or bile does not flow into the gallbladder and duodenum. This occurs when a condition called bile duct disease develops. cholestatic liver disease Characterized by degeneration of of liver tissue, scar tissue formation, and chronic inflammation. The consequences of this condition can be very serious, and if left untreated, liver failure, cirrhosis, and liver transplantation.
Types of biliary stasis liver disease.
Primary biliary cirrhosis (PBC).
This refers to a disorder of the intrahepatic bile ducts. It occurs rarely. disease 40 of 100,000 people are affected, with women at highest risk. disease Although the field this is called early biliary cirrhosis, it is worth noting that cirrhosis does not occur until later stages of the disease. the disease .
- Symptoms: It takes a long time for signs to be established, and generalized fatigue is usually considered the first sign of PBC. Nevertheless, itching and itching may remain. Almost all patients do not feel any signs, especially in the early stages. Late signs include darker urine, yellowing of the skin and eyes, and cholesterol accumulation around the eyes and skin.
- Causes: The true cause has not yet been identified, but experts believe it is due to environmental and genetic causes. Experts believe it is autoimmune. disease .
- Treatment: Doctors make the diagnosis by determining the presence or absence of anti-mitochondrial antibodies. If there is evidence, they will address it. cholestatic liver disease Treatment with ursodeoxycholic acid (UDCA), considered the only readily available drug, works in 60% of patients. Some people are at higher risk of developing diabetes liver dysfunction and cirrhosis. They need the following liver transplantation.
Primary Sclerosing Cholangitis (PSC)
This affects the paracolic and intramedullary bile ducts, causing inflammation of the bile ducts. It causes narrowing of the bile ducts, leading to a buildup of bile. the liver Field creation is damaging. to liver Cells are destroyed, causing cancer and cirrhosis.
- Drawing: early signs are abdominal pain and itching. Although most patients remain asymptomatic in the early stages, liver Functional studies show a difference. More advanced signs are right upper quadrant pain, yellow und, tremors, and fever.
- CAUSE: Like PBC, PSC is an autoimmune disease, although the preconditions for PSC have not yet been identified. disease The disease develops very slowly.
- Treatment: as with PBC, most patients have been shown to need to be cured from UDCC, but in the case of PSC there is no treatment that reduces the need for cure. for liver Patient Transplantation.
Biliary Stasis of Pregnancy
Biliary stasis is a condition in which there is an outflow of bile from the liver . Many women develop this disease during pregnancy. There is a little more about this cholestatic liver disease .
Symptoms
This disease develops during pregnancy and causes severe itching in the legs and arms. You can still experience itching in other parts of the body, it increases at night. Other symptoms associated with cholestasis pregnancy include nausea, skin and eye fing formula, and loss of appetite. While this situation can cause you much discomfort, it is not the least long-term risk to the pregnant mother. However, it may not be safe for the developing baby, in which case early family is recommended.
Treatment
Your doctor will give you prescribed medications and offer other medications to relieve the severe itching. He or she may give you the drug Ursodiol, which helps reduce the amount of bile in the blood. It also reduces the burden on the developing baby. A week itchy area of hot water also helps.
Prevent complications.
Your doctor pays attention to your pregnancy and your baby’s development. a cholestatic liver disease Severe aggravation can cause the baby to grow. Your doctor can take different measures depending on your condition. For example:
- They will plan a biophysical profile test and a non-stress test to check the baby’s well-being. The non-stress analysis helps determine how much the baby moves in a given amount of time. It also talks about the increase in heart rate during exercise. A biophysical profile, on the other hand, provides complete information about fetal muscle tone, amniotic fluid size, and fetal force.
- Even if your prenatal tests show virtually no abnormalities, they can suggest early induction of the family. This happens when you are already 37 weeks pregnant. Early family is the best way to prevent fetal collapse.
Biliary stasis in the newborn
This condition refers to the inability to separate bilirubin, leading to a buildup of bilirubin in the blood. This also means that the amount of bile salts in the gastrointestinal tract is reduced. Inadequate bile in the gastrointestinal tract makes it difficult for the child to eat fat and fatty vitamins. This can lead to inadequate food, vitamin deficiencies, and lifting problems.
Symptoms
This cholestatic liver disease Take your children in the direction of the first few months of life. lives Your baby will develop yellow und, aschool stool, black urine, liver tumors. Acquired itching is still considered a common sign and usually indicates a deficiency of fat-soluble vitamins. If there is a major disorder, this can lead to dilated abdominal veins and ascites, which can still lead to the development of portal hypertension. Gastrointestinal variants may in some cases lead to bleeding in the upper abdomen.
Treatment
Treatment depends on the underlying cause. Health care providers usually stick to caloric therapy when there is no specific therapy available for the underlying condition. Nutritional therapy can consist of vitamin K, E, D, and A supplements. Babies should exceed 130 calories/kg per day; ursodeoxycholic acid in doses of 10-15 mg/kg once per day still helps relieve itching.
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