Chanca Piedra Side Effects

Chanca piedra pills or capsules contain anywhere from 500 to 1,600 mg of the herb per dose, and liquid extracts contain a similar amount.

CHANCA PIEDRA – Uses, Side Effects, and More

Chanca piedra, which means “stone breaker” in Spanish, is a small herb. Both Phyllanthus niruri and P. amarus have been called chanca piedra.

Chanca piedra has traditionally been used for kidney stones. It’s thought that chanca piedra contains chemicals that might relieve spasms and increase urine. It is also thought to have activity against bacteria and viruses.

People use chanca piedra for kidney stones. It is also used for hepatitis B, stomach pain, asthma, diabetes, and many other conditions, but there is no good scientific evidence to support these other uses.

Uses & Effectiveness ?

Possibly Effective for

Kidney stones. Taking chanca piedra by mouth seems to help clear some kidney stones. But it is unclear which people are most likely to benefit from chanca piedra.

Likely InEffective for

Swelling (inflammation) of the liver caused by the hepatitis B virus (hepatitis B). Taking chanca piedra by mouth does not improve hepatitis B symptoms.

Side Effects

When taken by mouth: Chanca piedra is possibly safe when used for up to 3 months. Side effects might include stomach pain and nausea.

When applied to the skin: There isn’t enough reliable information to know if chanca piedra is safe or what the side effects might be.

Special Precautions and Warnings

When taken by mouth: Chanca piedra is possibly safe when used for up to 3 months. Side effects might include stomach pain and nausea.

When applied to the skin: There isn’t enough reliable information to know if chanca piedra is safe or what the side effects might be.

Pregnancy: Chanca piedra is possibly unsafe when used during pregnancy or by those trying to become pregnant. Taking chanca piedra, especially in high doses, might block pregnancy, increase the risk of low birth weight, or increase the risk of birth defects.

Breast-feeding: There isn’t enough reliable information to know if chanca piedra is safe to use while breast-feeding. Stay on the safe side and avoid use.

Bleeding disorder: Chanca piedra might slow blood clotting. Taking chanca piedra might cause bleeding in people with bleeding disorders.

Surgery: Chanca piedra might lower blood sugar levels. This might interfere with blood sugar control during and after surgery. Chanca piedra might also slow blood clotting and increase the risk of bleeding. Stop using chanca piedra at least 2 weeks before a scheduled surgery.

Interactions ?

Moderate Interaction

Be cautious with this combination

Lithium interacts with CHANCA PIEDRA

Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with CHANCA PIEDRA

Norepinephrine (Levophed) interacts with CHANCA PIEDRA

Water pills (Diuretic drugs) interacts with CHANCA PIEDRA

Minor Interaction

Be watchful with this combination

Medications for diabetes (Antidiabetes drugs) interacts with CHANCA PIEDRA

Medications for high blood pressure (Antihypertensive drugs) interacts with CHANCA PIEDRA

Dosing

There isn’t enough reliable information to know what an appropriate dose of chanca piedra might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.

REFERENCES:

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Barros, M. E., Lima, R., Mercuri, L. P., Matos, J. R., Schor, N., and Boim, M. A. Effect of extract of Phyllanthus niruri on crystal deposition in experimental urolithiasis. Urol.Res 2006;34(6):351-357. View abstract.

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Bhattacharjee, R. and Sil, P. C. The protein fraction of Phyllanthus niruri plays a protective role against acetaminophen induced hepatic disorder via its antioxidant properties. Phytother.Res 2006;20(7):595-601. View abstract.

Bhattacharyya R, Bhattacharya S Wenzel-Mathers M et al. Phyllanthus amarus root clone with significant activity against bovine viral diarrhoea virus – a surrogate model of hepatitis C virus. Current Science 2003;84(4):529-533.

Blumberg, B. S., Millman, I., Venkateswaran, P. S., and Thyagarajan, S. P. Hepatitis B virus and hepatocellular carcinoma–treatment of HBV carriers with Phyllanthus amarus. Cancer Detect.Prev. 1989;14(2):195-201. View abstract.

Blumberg, B. S., Millman, I., Venkateswaran, P. S., and Thyagarajan, S. P. Hepatitis B virus and primary hepatocellular carcinoma: treatment of HBV carriers with Phyllanthus amarus. Vaccine 1990;8 Suppl:S86-S92. View abstract.

Boim, M. A., Heilberg, I. P., and Schor, N. Phyllanthus niruri as a promising alternative treatment for nephrolithiasis. Int.Braz.J Urol. 2010;36(6):657-664. View abstract.

Brook, M. G. Effect of Phyllanthus amarus on chronic carriers of hepatitis B virus. Lancet 10-29-1988;2(8618):1017-1018. View abstract.

Campos, A. H. and Schor, N. Phyllanthus niruri inhibits calcium oxalate endocytosis by renal tubular cells: its role in urolithiasis. Nephron 1999;81(4):393-397. View abstract.

Chatterjee, M. and Sil, P. C. Hepatoprotective effect of aqueous extract of Phyllanthus niruri on nimesulide-induced oxidative stress in vivo. Indian J Biochem Biophys. 2006;43(5):299-305. View abstract.

Chatterjee, M., Sarkar, K., and Sil, P. C. Herbal (Phyllanthus niruri) protein isolate protects liver from nimesulide induced oxidative stress. Pathophysiology. 2006;13(2):95-102. View abstract.

Chezhiyan N, Saraswathy S Vasumathi R. Studies on organic manures, biofertilizers and plant density on growth, yield and alkaloid content of bhumyamalaki (Phyllanthus amarus Schum. and Thonn.). South Indian Horticulture 2003;51:96-101.

Chitra R, Vadivel E Rajamani K. Estimation of anti-hepatic viral compounds in Phyllanthus amarus in vitro cultures. Journal of Horticultural Sciences 2008;62-65.

Cimanga, R. K., Tona, L., Luyindula, N., Mesia, K., Lusakibanza, M., Musuamba, C. T., Apers, S., De, Bruyne T., Van, Miert S., Hermans, N., Totte, J., Pieters, L., and Vlietinck, A. J. In vitro antiplasmodial activity of callus culture extracts and fractions from fresh apical stems of Phyllanthus niruri L. (Euphorbiaceae): part 2. J Ethnopharmacol. 2004;95(2-3):399-404. View abstract.

Dirjomuljono, M., Kristyono, I., Tjandrawinata, R. R., and Nofiarny, D. Symptomatic treatment of acute tonsillo-pharyngitis patients with a combination of Nigella sativa and Phyllanthus niruri extract. Int J Clin Pharmacol.Ther 2008;46(6):295-306. View abstract.

Doshi, J. C., Vaidya, A. B., Antarkar, D. S., Deolalikar, R., and Antani, D. H. A two-stage clinical trial of Phyllanthus amarus in hepatitis B carriers: failure to eradicate the surface antigen. Indian J Gastroenterol. 1994;13(1):7-8. View abstract.

Etta H. Effects of Phyllanthus amarus on litter traits in albino rats. Scientific Research and Essays 2008;370-372.

Etta HE, Udoh PB Asuquo BO et al. Effect of Phyllanthus amarus on breeding efficiency of female albino rats. Global Journal of Agricultural Sciences 2007;215-217.

Faremi, T. Y., Suru, S. M., Fafunso, M. A., and Obioha, U. E. Hepatoprotective potentials of Phyllanthusamarus against ethanol-induced oxidative stress in rats. Food Chem Toxicol. 2008;46(8):2658-2664. View abstract.

Foo LY. Amariin, a di-dehydrohexahydroxydiphenoyl hydrolysable tannin from Phyllanthus amarus. Phytochemistry 1993;33(2):487-491.

Foo LY. Amariinic acid and related ellagitannins from Phyllanthus amarus. Phytochemistry 1995;39(1):217-224.

Freitas, A. M., Schor, N., and Boim, M. A. The effect of Phyllanthus niruri on urinary inhibitors of calcium oxalate crystallization and other factors associated with renal stone formation. BJU.Int. 2002;89(9):829-834. View abstract.

Gupta AK, Khanuja SP Gupta MM et. al. High herb, phyllanthin and hypophyllanthin yielding variety of bhumyamalaki (Phyllanthus amarus): Cim-Jeevan. Journal of Medicinal and Aromatic Plant Sciences 2003;25(3):743-745.

Harikumar, K. B., Kuttan, G., and Kuttan, R. Inhibition of viral carcinogenesis by Phyllanthus amarus. Integr.Cancer Ther. 2009;8(3):254-260. View abstract.

Harikumar, K. B., Kuttan, G., and Kuttan, R. Phyllanthus amarus inhibits cell growth and induces apoptosis in Dalton’s lymphoma ascites cells through activation of caspase-3 and downregulation of Bcl-2. Integr.Cancer Ther. 2009;8(2):190-194. View abstract.

Huang ZR, Zhong JP, and Zhu GL. Therapeutic observation of Phyllanthus amarus for treatment of hepatitis B . The Cochrane Library 1993;(1)

Hussain RA, Dickey JK Rosser MP et al. A novel class on non-peptidic endothelin antagonists isolated from the medicinal herb Phyllanthus niruri. Journal of Natural Products 1995;1515-1520.

Iizuka, T., Moriyama, H., and Nagai, M. Vasorelaxant effects of methyl brevifolincarboxylate from the leaves of Phyllanthus niruri. Biol.Pharm.Bull. 2006;29(1):177-179. View abstract.

Iizuka, T., Nagai, M., Taniguchi, A., Moriyama, H., and Hoshi, K. Inhibitory effects of methyl brevifolincarboxylate isolated from Phyllanthus niruri L. on platelet aggregation. Biol.Pharm.Bull. 2007;30(2):382-384. View abstract.

Jayaram S, Thyagarajan SP Sumathi S et al. Efficacy of Phyllanthus amarus treatment in acute viral hepatitis A, B and non A non B: an open clinical trial. Indian Journal of Virology 1997;13(1):59-64.

Jayaram, S. and Thyagarajan, S. P. Inhibition of HBsAg secretion from Alexander cell line by Phyllanthus amarus. Indian J Pathol.Microbiol. 1996;39(3):211-215. View abstract.

Jeena, K. J., Joy, K. L., and Kuttan, R. Effect of Emblica officinalis, Phyllanthus amarus and Picrorrhiza kurroa on N-nitrosodiethylamine induced hepatocarcinogenesis. Cancer Lett. 2-8-1999;136(1):11-16. View abstract.

Joshi H, Parle M. Evaluation of the antiamnesic effects of Phyllanthus amarus in mice. Colombia Medica 2007;132-139.

Joy KL, Kuttan R. Inhibition by Phyllanthus amarus of hepatocarcinogenesis induced by N-nitrosodiethylamine. Journal of Clinical Biochemistry and Nutrition 1998;24(3):133-139.

Karuna, R., Reddy, S. S., Baskar, R., and Saralakumari, D. Antioxidant potential of aqueous extract of Phyllanthus amarus in rats. Indian J Pharmacol. 2009;41(2):64-67. View abstract.

Khanna, A. K., Rizvi, F., and Chander, R. Lipid lowering activity of Phyllanthus niruri in hyperlipemic rats. J Ethnopharmacol. 2002;82(1):19-22. View abstract.

Kiemer, A. K., Hartung, T., Huber, C., and Vollmar, A. M. Phyllanthus amarus has anti-inflammatory potential by inhibition of iNOS, COX-2, and cytokines via the NF-kappaB pathway. J Hepatol. 2003;38(3):289-297. View abstract.

Krithika, R. and Verma, R. J. Ameliorative potential of Phyllanthus amarus against carbon tetrachloride-induced hepatotoxicity. Acta Pol.Pharm. 2009;66(5):579-583. View abstract.

Krithika, R. and Verma, R. J. Mitigation of carbon tetrachloride-induced damage by Phyllanthus amarus in liver of mice. Acta Pol.Pharm. 2009;66(4):439-444. View abstract.

Kumar MS, Jaiprakash B Hukkeri VI. Preventive effect of Phyllanthus amarus on prostatic hyperplasia. Hamdard Medicus 2006;114-117.

Kumar NG, Nair AN Raghunandanan VR et al. Hypoglycaemic effect of Phyllanthus niruri leaves in rabbits. Kerala Journal of Veterinary Science 1989;20(1):77-80.

Kumar, K. B. and Kuttan, R. Chemoprotective activity of an extract of Phyllanthus amarus against cyclophosphamide induced toxicity in mice. Phytomedicine. 2005;12(6-7):494-500. View abstract.

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Chanca Piedra: Benefits, Dosage, Side Effects, and More

Chanca piedra is an herb that grows in tropical areas, like the rainforests of South America. Its scientific name is Phyllanthus niruri.

It also goes by a number of other names, such as:

stone breaker
gale-of-the-wind
seed-under-leaf
quebra pedra
shatter stone
chance pierre

The plant has thin, leaf-covered branches and can grow up to about 2 feet (61 cm) tall. It gets the name “seed-under-leaf” because its seed pods, which bloom into small green flowers, grow beneath the leaves.

The entire plant — including the leaves, stems, and flowers — is used to make chanca piedra supplements.

As a supplement, chanca piedra is reported to help with a variety of conditions related to the digestive system, liver, and kidneys.

Supposedly, it contains phytochemicals — or plant compounds — that can increase urine flow, kill harmful bacteria and viruses, and relieve inflammation ( 1 ).

However, there’s little evidence that it’s effective.

Chanca piedra is available in teas, liquid extracts, capsules, or tablets.

According to some claims, chanca piedra may have several beneficial effects on different body systems. However, there’s little research to support these claims.

Kidney stones

Chanca piedra is best known as a potential kidney stone cure — which is how it earned the name “stone breaker.”

The herb is alkaline, so it may help prevent acidic kidney stones. It’s a less expensive, over-the-counter alternative to prescription potassium citrate, an alkalizing agent that’s commonly used to prevent acidic kidney stones. It may also help you urinate more ( 2 ).

In one study of 56 people with kidney stones who took 1 cup of hot water infused with an herbal sachet containing 4.5 grams of chanca piedra twice daily, researchers found that the kidney stones decreased in size and number in about two-thirds of participants ( 3 ).

What’s more, other small human studies have observed some benefit to taking chanca piedra for kidney stones ( 4 ).

Stomach ulcers

Chanca piedra extract can kill the bacterium that causes stomach ulcers from Helicobacter pylori in test-tube studies. However, this doesn’t necessarily translate to an oral supplement being effective against stomach ulcers in humans ( 5 , 6 ).

Test-tube studies like these typically involve highly concentrated extracts being applied directly to bacterial cells, which isn’t how oral chanca piedra supplements would work.

High blood sugar

In animal studies, the antioxidants in chanca piedra have been able to improve fasting blood sugar levels, which can help with blood sugar management ( 1 , 7 ).

Still, this doesn’t necessarily mean that chanca piedra would have the same effect in humans.

More research is needed to understand the effect of chanca piedra on blood sugar levels in humans.

Gallstones

For the same reason it may help with kidney stones, the alkalizing properties of chanca piedra may help prevent gallstones as well. It’s used in some traditional medicine practices as a gallstone treatment ( 1 ).

Yet, there’s no scientific evidence to support the use of chanca piedra specifically for gallstones.

Gout

Gout flare-ups can occur when high levels of uric acid build up in the blood. Chanca piedra may help balance out these levels and prevent gout attacks.

Some animal studies have shown a decrease in uric acid levels in animals receiving chanca piedra supplements ( 1 ).

Liver disease

Due to its antioxidant content, chanca piedra may improve liver function and help protect the liver from cellular damage caused by free radicals — unstable compounds that can cause damage when they build up in your body in high levels ( 1 ).

The herb also appears to be helpful for treating hepatitis B, an inflammatory viral infection of the liver — at least in animal and test-tube studies ( 1 ).

Because some other herbs in the Phyllanthus genus exhibit strong antiviral activity against hepatitis B — potentially rivaling that of the antiviral medication interferon — researchers theorize that chanca piedra may have similar effects ( 1 ).

Still, most of this research has been done in animal or test-tube studies. More human studies are needed to assess the effects of chanca piedra on liver health.

High blood pressure

Some animal research indicates that chanca piedra may help relax the blood vessels, which could lead to reductions in blood pressure ( 1 ).

Yet, one human study noted a slight, but not clinically significant, increase in blood pressure in participants while taking chanca piedra for 12 weeks. However, these participants saw a significant reduction in blood pressure over the 12 weeks after they stopped taking the chanca piedra (3).

It’s important to note that most of the existing research on chanca piedra has been done in animals or test tubes, using highly concentrated extracts.

Although there’s a small amount of evidence to support the use of chanca piedra for kidney stones in humans, larger and more rigorous human studies are needed to determine if chanca piedra truly has any benefits.

In one human study, some of the reported side effects of chanca piedra supplementation included:

abdominal pain
painful urination
blood in the urine
nausea

Abdominal pain was by far the most common, with the others being much less commonly reported ( 3 ).

Chanca piedra may also reduce blood sugar and blood pressure levels, so it should be used with caution if you’re on a blood pressure or blood sugar lowering medication ( 1 ).

Keep in mind that supplements aren’t regulated by any government organizations, so there’s little oversight to ensure that the label is an honest representation of what’s in the supplement.

If you choose to take chanca piedra, you should buy a supplement that has been independently verified for quality by a third party organization. Some of these organizations include ConsumerLab, NSF International, and United States Pharmacopeia (USP).

In one human study that showed improvements in kidney stones, the daily dosage was 4.5 grams of chanca piedra infused in one cup of hot water twice daily for 12 weeks ( 3 ).

Chanca piedra pills or capsules contain anywhere from 500 to 1,600 mg of the herb per dose, and liquid extracts contain a similar amount.

It’s difficult to tell how much of the herb you would consume from tea, as the amount of the herb that infuses into the tea depends on the temperature of the water and how long the tea steeps.

Chanca piedra can be taken with or without food.

There’s no research on the long-term effects of chanca piedra, so it may be wise to limit the time you take the supplement to 12 weeks or less — a duration that has been studied in humans ( 3 ).

In the studies that have been done on chanca piedra, there doesn’t appear to be any risks to stopping the supplement suddenly. There are also no reported withdrawal symptoms.

However, because there’s a lack of research, it’s possible that some complications simply haven’t been explored yet.

If you’re experiencing any issues when stopping chanca piedra, be sure to consult a healthcare provider.

There’s not enough research available to suggest that chanca piedra overdose is possible.

Still, you should limit the amount you take to the daily dose on the supplement label, as there could be safety concerns with high doses of chanca piedra that haven’t been studied yet.

Chanca piedra has the potential to interact with several medications, including:

Lithium. Chanca piedra may make you urinate more, which can affect the way your body gets rid of lithium ( 3 ).
Blood pressure lowering drugs. The herb may lower your blood pressure, which can potentially lead to low blood pressure levels, especially in people who are already on blood pressure medications ( 1 ).
Blood sugar lowering drugs. Chanca piedra may decrease your blood sugar levels. If you’re already on insulin or other drugs that lower blood sugar, this can lead to dangerously low levels known as hypoglycemia ( 1 ).
Blood thinning medications. Chanca piedra may inhibit blood clotting, which can lead to severe complications in people who are on blood thinners ( 1 ).

Chanca piedra supplements in any form — tea, extract, or pills — should be kept in a cool, dry place where they won’t be exposed to excessive moisture or temperature changes.

Most chanca piedra supplements have an expiration date that’s set about 2 years after production. To ensure potency and safety, use your chanca piedra supplements before they expire.

There’s not enough evidence available regarding the safety of chanca piedra during pregnancy or breastfeeding. Therefore, it’s best to avoid it while pregnant, trying to get pregnant, or breastfeeding.

Be sure to consult a healthcare provider if you have any concerns about chanca piedra and pregnancy or breastfeeding.

Because little is known about chanca piedra, you should consult a healthcare provider before giving the supplement to children or adolescents.

People with type 1 or type 2 diabetes should also use this supplement with caution, as it may decrease blood sugar levels. In people who are already taking insulin or other blood sugar lowering medications, this could lead to hypoglycemia ( 1 ).

Because it may affect kidney function, people with chronic kidney disease or other kidney problems should consult a healthcare professional before using chanca piedra.

Some alternatives to chanca piedra for kidney stones include other alkalizing agents like sodium bicarbonate or potassium citrate. Potassium citrate is most commonly used for kidney stones, and it’s available over-the-counter or in prescription strength ( 2 , 8 ).

Because there’s so little evidence available about the effectiveness of this herb, you should consult a healthcare professional if you have any health problems that you feel chanca piedra may help with.

Last medically reviewed on March 24, 2023

How we reviewed this article:

Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available.

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Chanca Piedra Side Effects

CHANCA PIEDRA – Uses, Side Effects, and More