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Atropine is a toxic complication found in the deadly Belladonna plant. Atropine is used as a muscle relaxant that inhibits nerve response and dilates the pupil of the eye. It can possibly be administered by eye drops, injection, or recorded orally. The atropine mechanism of action It is classified as an antiparasamphetamine (parasympathomimetic) or anticholinergic product. It is an antimuscarinic explorer because it prevents the thymic carinergic behavior of acetylcholine and other choline esters.
What is atropine used for?
Atropine reduces mouth excretion, reduces respiratory tract excretion, relieves spasm, and relieves airway narrowing. Atropine can further reduce respiratory paralysis as a result of the actions of toxic substances in the central nervous system prior to surgery. Atropine-induced paracardiocentrism may be more useful in the heart, where tachycardia is caused by paralysis of vagal control. Small doses of atropine Slows the rate of cardiac contraction before the characteristic tachycardia occurs. It is still used to treat spasms of the intestinal tract, stomach, and other organs. It can still be used as an anticholinergic the effects acetylcholine in the stomach, intestinal tract, nervous system, urinary tract, certain glands and other tissues.
Atropine Operation
1. vascular action
- Cardiac action : The atropine leads to changes in the frequency of falls in the heart. At low doses, a small delay in the heart is explained by an incidental parasympathetic effect Central vagal stimulation leads to short-term structure of acetylcholine. Usually, when small doses are large, the heart is accelerated by way of breaking down reflex low cardia and reducing vagal tone against a background of arterial hypertension.
- Arterial pressure behavior: Atropine in therapeutic doses does not cause an arterial pressure configuration, even in the case of increased heart rate, and has no vascular effect. effects However, significantly higher or toxic doses cause a decrease in blood pressure by inhibiting cutaneous vasodilation and vasomotor centers that may be secondary to histamine release.
2. acute exposure
- Atropine eye causes passive myopathy or pupil dilation and increases the iris crossing section, thus masking the parasympathetic effect on the eye.
- In the treatment of people predisposed to narrow angle glaucoma, C atropine tends to increase intraocular pressure, which interferes with the evacuation of the aquarium (the clear fluid that obstructs the anterior part of the eye’s location between the lens and the cornea) and Schlemm’s canal.
- Atropine has the property of causing paralysis of the ciliary muscles or cycloplegic policy, which actually leads to visual impairment.
- The atropine mechanism of action This can last for quite a long time and the dilation of the pupil can last for several days.
3. effect on smooth muscles
- With the exception of the vascular muscles, acetylcholine causes smooth muscle to glide, and atropine By inhibiting this acetylcholine, there is a seizure response effect .
- Atropine also acts in the gastrointestinal tract by reducing the amplitude, tone, and frequency of contractions. It works well in combination with morphine because it reduces the hypertonicity induced by morphine in the treatment of intestinal pain.
- The bronchi, bile ducts, urinary tract, and bladder still seem to be auto-nervated. The ureters still receive parasympathetic and sympathetic innervation; the sympathetic nerves dilate the ureters and compress the sphincter muscles. Not the least important is that the urethra squeezes the urethra and relaxes the internal sphincter, especially in the case of prostatic hypertrophy.
4. effect on the partition
- Digestive system: The atropine mechanism of action In the digestive system, inhibits the salivary layer, causes dry mouth, greatly reduces the production of gastric acid and promotes healing of gastric ulcers.
- Bronchia: The effect of atropine Decreases sp or mucus production in patients with asthma and bronchitis.
- Skin: atropine can be used to control the sardation or sweating process. the action sweating process. However, care should be taken on hot days, as inhibition of the sweating process may lead to hyperthermia.
- Eye: Atropine helps keep excessive complaints and laceration isolation under control.
Possible side effects of atropine
- Large sidewares. effects of atropine directly related to their antimuscarinic properties. However, they may still blur vision, dry mouth, photophobia, and tachycardia. This is usually seen at low doses of acquired initiation.
- Another side effect zoonosis, or the inability to sweat. This can lead to overheating and sometimes hyperthermia, a potentially fatal condition.
- In older patients, difficulty urinating and constipation may occur. Other Side Effects. effects include dilated pupils, heart palpitations, hot dry skin, difficulty swallowing, thirst, excitement, dizziness, tremors, ataxia, and fatigue.
- Toxic doses have every opportunity to lead to embodied fear, disability, delirium, hallucinations, com sleep. Volume poisoning can lead to a collapse of blood circulation with a drop in blood pressure, followed by paralysis, com sleep, and finally death due to lack of respiration.
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