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High alkaline phosphatase (ALP) levels probably indicate liver damage or a pattern of bone abnormalities. Liver damage gives a different ALP pattern than bone disease. If test results indicate high ALP levels, the physician may be able to run additional tests, such as an ALP isoenzyme test, to determine where the additional ALP is coming from.
Alkaline Phosphatase
The Alkaline Phosphata Test (ALP) determines the amount of ALP in your blood; ALP is an enzyme that occurs in many parts of your body. All parts of your body create different patterns of ALP; the majority of ALP is found in the liver, bones, kidneys, and digestive system.
Abnormal ALP levels in the blood are probably a symptom of numerous diseases, including liver damage, bone damage, and chronic kidney damage. However, since alkaline phosphatase alone cannot identify the most important ALP in the blood, other tests are usually needed to make a diagnosis.
Other names: ALP, ALK, PHOS, ALKP, ALK PH OS.
What is it used for?
The alkaline phosphata test is often used to support the diagnosis of liver or bone disease. The test can also help diagnose or check other health conditions.
Why is an alkaline phosphata test needed?
Care providers can order an alkaline phosphatase analysis as part of routine testing. Often the analysis is done in conjunction with other blood tests because almost any situation can affect ALP levels. These other tests include an extensive metabolic panel (CMP) or liver function test that checks how well the liver is functioning.
If there are signs of liver or bone damage, an alkaline phosphata test can be ordered. Signs of liver disease include
- Nausea and vomiting
- lack of appetite
- Fatigue
- Weakness
- Yellow und, a condition in which your skin and pre turns yellow
- Swelling or pain in the abdomen (abdomen)
- Swollen ankles and legs
- Dark urine and/or clear stools
- Normal itching
Symptoms of bone disorders include
- Pain in your bones
- Joint inflammation and arthritis
- Abnormally formed and/or very large bones
- Fractures
What happens during the alkaline phosphata test?
The alkaline phosphata test is a blood test. During the test, a doctor with a small needle takes blood from a vein in your arm. After the needle is inserted, a small amount of blood is collected in a test tube or vial. Some pressure can be felt as the needle goes in and out. This usually takes less than 5 minutes.
Need to prepare for the test?
Preparation for the alkaline phosphata test depends on the laboratory where the test will be performed. Some labs ask you to fast (do not eat or drink) 6-12 hours before the test. In addition, the ALP test is usually performed in conjunction with other blood tests. Usually these tests require fasting for several hours. Your doctor will tell you if there are any special instructions you should follow.
Were there any risks associated with the tests?
There are no sufficient risks associated with blood tests. You can have slight soreness and bruising in the area where the needle is inserted, but most signs disappear quickly.
What do the results mean?
High alkaline phosphatase (ALP) levels can be a symptom of liver problems and bone disorders. Liver problems and bone disorders can be caused by different types of ALP. However, test results cannot indicate which ALP patterns are high.
If the test results show high ALP levels, the physician can order other studies to help determine what the problem is. These tests are as follows
- Alp-Isoenzymanalysis.This test lets you know which parts of your body make ALP. However, this test may not be available everywhere.
- Liver Function Test. If the results of these studies are still high, the increased degree of ALP is probably related to liver tasks.
Advanced alkaline phosphatase in the liver can be a symptom.
- Bile duct snacks
- Cirrhosis of the liver
- Hepatitis
- Monocleoses, which can cause liver swelling
If your alkaline phosphatase levels are high and your liver tests are normal, the problem could be bone disease, such as Paget’s bone disease. This disease makes your bones abnormally large and weak, making them more prone to breakage.
Moderately high ALP levels can be a symptom of many different types of disorders, such as Hodgkin’s lymphoma, heart deficiency, or certain infections.
It is possible to have higher than normal ALP levels and not have an illness that needs to be treated urgently. Your physician will look at your symptoms, disease status, and other test results to make a diagnosis.
Low ALP levels are not very common. They can be a symptom of zinc deficiency, malnutrition, adverse anemia, thyroid disease, Wilson’s disease, or rare genetic disorders affecting the pituitary gland, bones or teeth.
Is there anything else I should know about alkaline phosphata testing?
Many baggage can affect ALP values. Pregnancy can cause higher than normal ALP values. Babies and young adults can have increased ALP levels as their bones grow. Birth control pills and some medications can lower ALP, while others can increase ALP. Use of fatty foods before an alkaline phosphata test may slightly increase ALP.
To know what the results mean you can talk to your internet provider.
Recommendations
- American Liver Foundation.[Internet]. New York: Liver Foundation of South America. c2017. diagnosis of liver disease – liver biopsy and liver function studies; [updated February 17, 2020. cited February 16, 2022]; [3 more screens]. available at https: // liverfoundation. org/for-patients/ liver/ diagonesing-liver-disease/
- Centers for Disease Control and Prevention [Internet]. Atlanta: U.S. Department of Health and Human Services. epstein-Barr microbe and infectious mononucleosis; [reviewed September 28, 2020; cited February 16, 2022]; [about 2 screens]. Available: https: // www. CDC.Gov/Epstein-Barr/About-Mono. HTML
- Hinkle J., Cheever K. Brunner, and Suddarth, Handbook of Laboratory and Diagnostic Testing. 2nd ed. Kindle. philadelphia: Wolters Kluwer Health, Lippincott Williams & amp; Wilkins; C2014. alkaline phosphate; p. 35-6.
- Johns Hopkins Medicine [Internet]. Johns Hopkins Institute. c2022. bone disease; [cited 2017 Mar 13]; [about 4 screens]. by: https: // www. hopkinsmedicine. Organizations/ Health/ Conditions and Diseases/ Paget’s Disorder of Bone.
- Joss, R. G., Hanley, D. A., Kendler, D., Ste-Marie, L. G., Adachi, D. D., Brown, J. Diagnosis and healing of bone disease.Clin Invest Med [Internet] 2007 [cited 2017 Mar 13]; 30(5):E21 0-23. by: https: // www. ncbi. nlm. nih (National Institutes of Health. Gov/PubMed/17892763/
- Merck Manual Cherpentieversie [Internet]. Kenilworth, NJ: Merck & amp; Co. Inc; C2022. Lever En Galblaas LaboratoriumControles; [cited 2017 Mar 13]; [about 3 screens]. Beschikbaar Via: https:// www. merck-manual. com/professional/ liver-and-bile/ hepatic-and-biliary-diseorders/laboratory-tests-fth-hooliver-and-gallbladder #3178881
- National Heart, Heart, and Bloodhea [Internet].Bethesda (MD): U.S. Department of Health and Human Services. Blood Test Dangers; [cited February 16, 2022]; [about 16 screens].Beschikbaar OP: https: // www. nhlbi. NIH (National Institutes of Health. Gov/Health-Topics/Blood-Tests.
- NIH U.S. Government Book Depository Medicine: Genetics Home HyperLink [Internet]. bethesda (MD): U.S. Department of Health and Human Services. dypofosfatasie; 2017. 7 Maart [laatst bessproken: 2018 1 Maart; Geciteerd 2022 16 Februari]; [6 or more shamans]. beschikbaar via: https: / / ghr. NLM. nih. nih (National Institutes of Health. Gov/ state/ hypophosphatasie.
- NIH National Osteoporosis and Related Bone Diseases is a resource central [Internet]. bethesda (MD): US Department of Health and Human Services. eigenlijk wat is de botziekte van paget? Sudden antecedents: the usual reading series for the public; [Laatst Besproken 2019 Sept. Geciteerd 2022 16 Februari]; [more than 9 shamans].Beschikbaar Via: https: // www. Niams. NIH (US National Institutes of Health. Institute. gov/health_info/bone/pagets/pagets_disease_ff. ASP
- Lowe D, Sanvictores T, John S. Alkalische Fosfatase. uitgeverij statpearls [Internet]. Treasure Peninsula (Florida): [Laatst Bijgewerkt 2021 11 Augustus; Geciteerd 2022 16 Februari]; [6 or more shamans].Beschikbaar Via: https: // www. NCBI. NLM. NIH ( National Institutes of Health. gov/books/nbk459201/.
- Test. com [Internet]. Seattle, WA: OneCare Media; C2022. alkalische Fosfatase (ALP); [Gewijzigd 2021 9 Sept; Geciteerd 2022 17 Februari]; [12+ shamans]. beschikbaar OP: Retrieved from ” https: // www. tests. com/tests/alkalische-fosfatase-alp/.
- Rochester Institute Medical Midway [Internet]. Rochester, NY: Medisch Midden Van Het Rochester Institute; C2022. wellness encyclopedia: alkalische Fosfaat; [cited 2017 Mar 13]; [3 more Sherman]. Beschikbaar Via: Retrieved from ” https: // www. urmc. rochester. edu/enceclopedia/content. aspx? contentTypeID = 167 & amp; contentid = alkaline_phosphatase
- Wolters Kluwer [Internet]. uptodate Inc, C2022. alkaline phosphatase increase prerequisite; [version 7. 0; cited February 16, 2022]. [about 3 screens].Beschikbaar Via: https: // www. latest. com/contents/image?ImageKey = GAST%2F99099
VERWANTE GEZONDHEIDSONDERWERPEN
Alkali She Phosphatase (ALP)
Alkaline phosphatase (ALP) is an enzyme that occurs anywhere in the body; the ALP blood test is one of the tests that determine the extent of ALP in the blood, which originates from the liver and bones and is part of a comprehensive metabolic pathway. Increased amounts of ALP in the blood can indicate liver disease or certain bone disorders.
Overview
What is alkaline phosphatase (ALP)?
Alkaline phosphatase (ALP) is an enzyme that occurs anywhere in the body. Enzymes are images of proteins in cells that act as catalysts and enable certain bodily processes. Your body has thousands of enzymes with important functions.
Despite the fact that scientists understand the function of other different types of enzymes and have studied alkaline phosphatase for decades, they still do not understand the distinct function of ALP. However, scientists believe it is essential for different processes.
ALP is often a liver enzyme because it occurs primarily in the liver. Additionally, it is still in the right space there:
- Your bile ducts.
- Your bones.
- Your kidneys.
- Your intestines.
- Your placenta in a pregnant woman.
Abnormal ALP levels in the blood may indicate tissue damage or failure to follow normal body processes.
What is the Alkaline Phosphatase (ALP) Blood Test?
The Alkaline Phosphata Test (ALP) determines the number of ALP in your blood. However, ALP is found throughout your body, and the two most important sources of ALP in your blood are your liver and bones; high ALP levels may indicate liver disease or certain bone disorders, but once ALP is analyzed, no diagnosis can be made.
There are two important alkaline phosphatase (ALP) blood tests: arterial ALP (the better known test) and the ALP isoenzyme test.
The total ALP test is usually part of the blood tests known as group metabolism (CMP) and liver metabolism (HFP or LFT).
While the ALP test elementary determines the degree of ALP in the blood, the ALP isoenzyme test can distinguish between types of alkaline phosphatase based on where it occurs in the body.
If there was abnormal ALP due to previous testing, the care provider may be able to perform an ALP isoenzyme test as a follow-up test. However, isoenzyme testing may provide more thorough information, is more difficult and feasible on a technical level, and some labs may not offer it.
Why is an alkaline phosphatase blood test needed?
Physicians can order blood tests with alkaline phosphatase (ALP) to detect, control, or diagnose liver and bile disease, bone disease, and other health problems.
Screening means testing for health problems before symptoms occur; ALP analysis is often included in the broad metabolic pathway (CMP) and liver pathway. Medical suppliers often use these panels as part of routine screening tests for a wide range of health problems.
If you have liver or bone disease, or another lifestyle disorder, physicians often order an ALP test as part of the panel to see if it improves, deteriorates, or stays the same with or without treatment.
Physicians have the option of applying ALP analysis for research purposes in cases of possible liver or bone problems; ALP analysis has the opportunity to help diagnose the basis for more cumulative symptoms such as liver pavement or, when integrated into CMP, fatigue. However, health care providers cannot make a diagnosis based solely on ALP levels, which can be a necessary part of the diagnostic process; an increased or lower level of ALP than EASE may indicate a picture or severity of the condition.
Signs and indications of liver disease include
- Yellow und- the ability to force the skin and white eyes to yellowish.
- Abdominal pain (stomach) and/or swelling, especially on the right side.
- Simple bruising.
- Nausea and/or vomiting.
- Has black urine and / or light-colored dander.
- Unexplained weight loss.
- Fatigue.
- Swelling (edema) of arms and legs.
Signs and symptoms of bone disorders include
- Bone pain and/or joint pain.
- Enlarged and/or different bones.
- Increased incidence of bone fractures.
What is the difference between an alkaline phosphatase (ALP) test and a liver panel or extensive metabolic panel (CMP)?
A blood panel test includes one or more measurements of a blood sample. This provides more information than a liver panel or group metabolic panel (CMP) test for alkaline phosphatase alone. However, blood tests determined by ALP are often combined with other measurements, such as liver enzymes, to provide a more complete picture of liver health.
Test Details
Who is the Alkaline Phosphatase (ALP) blood test?
Caregivers, called ph lipidologists, usually take blood in what is attributed to the ALP blood test, but care providers trained to take blood can perform this task. The criteria are sent to a laboratory where scientists at a medical laboratory create the criteria and run the analysis on a machine called an analyzer.
Do I need to fast to test my blood for alkaline phosphatase?
If testing with alkaline phosphatase (ALP) is part of an extensive metabolic panel (CMP), you will probably need to fast for 10-12 hours for the CMP blood test. Fasting means no eating or drinking except for water.
Anyway, your caregiver will give you specific notes when he orders the blood test for you. It is imperative that you follow them.
What can I expect during an alkaline phosphatase (ALP) blood test?
During the blood test or blood tests, you can schedule yourself:
- You will sit in a chair and a caregiver will examine your hands for the presence of accessible veins. This is usually located on the inside of your arm opposite your elbow.
- If a vein is found, the area is cleaned and disinfected.
- Next, a small needle is placed in the vein to take a blood sample. This can be a small shot.
- When they put the needle in, a small amount of blood is sucked into the tubing.
- As soon as they have enough blood to find this, they remove the needle and keep cotton wool or gauze on the chamber to stop the bleeding.
- They place a bandage on the website and you are ready to go.
Usually the entire procedure takes less than 5 minutes.
What can I expect after an alkaline phosphatase blood test?
As soon as the doctor collects your blood sample, they will send it to the lab for testing. As soon as the test results come back, your caregiver will share the results with you.
What are the risks of alkaline phosphatase (ALP) testing?
Blood testing is considered a fairly common and necessary part of physical examinations and screenings. There are not sufficient risks associated with blood testing. There may be slight sensitivity or bruising in the area where the blood is taken, but this is usually over quickly.
When can I expect results from the Alkaline Phosphatase (ALP) test?
In most cases, test results are available within 1-2 business days, but it may take longer.
Results and Follow-up
What will be the results of the Alkaline Phosphatase (ALP) blood test?
Reports of blood tests, including reports of alkaline phosphatase (ALP) tests, usually provide the correct information.
- The name of the blood test or what was measured in the blood.
- The amount or measurement of the blood test result.
- The normal range of readings for this test.
- Information indicating whether the result is normal or abnormal, high or low.
What is the normal spectrum of alkaline phosphatase (ALP)?
The normal spectrum for alkaline phosphatase (ALP) varies from laboratory to laboratory. Normal reference spectra vary from 44 to 147 international units per liter (IE/L), although some organizations recommend spectra from 30 to 120 IE/L. Therefore, it is important to examine the test result reports to see what the reference spectrum is for a particular laboratory.
It is also important to know that normal values vary for alkaline phosphatase by age and gender; ALP values tend to increase during childhood and adolescence due to bone growth and maturation; between the ages of 15 and 50, ALP values in males are slightly higher than in females; ALP values increase again in old age ALP levels increase again in old age.
It can still be higher in pregnant women because ALP is found in the placenta and is the healer of fractures (rupture).
If my alkaline phosphatase (ALP) is high, what does that mean?
It is important to point out that increased ALP values have all the opportunity to be taxed differently. A fairly elevated ALP can mean that there is liver damage or bone disease, but almost any different reason can mean that the value is slightly increased – not necessarily due to a mysteriously necessary disease.If the ALP is slightly elevated, the care provider will probably not perform a major evaluation, they will not perform one. Instead, they will likely look at your values to make sure they are not getting worse.
High alkaline phosphatase (ALP) levels probably indicate liver damage or a pattern of bone abnormalities. Liver damage gives a different ALP pattern than bone disease. If test results indicate high ALP levels, the physician may be able to run additional tests, such as an ALP isoenzyme test, to determine where the additional ALP is coming from.
A high alkaline phosphata value in the liver is likely indicative of the correct condition.
- Biliary Stasis of Pregnancy: this is a popular liver disease that has a chance to develop at the end of pregnancy.
- Liver cirrhosis. Liver cirrhosis is a late stage liver disease in which healthy liver material is replaced by scar tissue and the liver is irreparably damaged.
- Hepatitis: Hepatitis is inflammation of the liver. There are numerous types of hepatitis.
- Biliary obstruction: This is a rare condition that occurs when the tubes (channels) that lead bile from the liver to the bile ducts are hidden. It occurs with young children.
- Biliary stricture. This condition occurs when the bile duct (the tube that conducts bile from the liver to the sensitive intestine) is narrowed or close.
- Obstruction of the bile duct due to cancer. Some forms of cancer, such as bile duct cancer or adenocarcinoma of the head of the pancreas, can block the bile duct or pancreatic tube.
- Mononucleosis (“mono”): this is a contagious infection and can sometimes cause swelling of the liver.
High vegetative phosphatase can indicate an appropriate condition.
- Bone metastasis. This condition occurs when cancer cells from other parts of the body spread to the bones.
- Paget’s Disease (Poliomyelitis): is a rare chronic bone disease (10) with excessive breakdown and renewed lifting of bone.
- Osteogenic sarcoma: is an image of a cancerous growth on the bone.
- Healing of fractures.
- Hyperparathyroidism. This condition occurs when the parathyroid glands isolate very large amounts of parathyroid hormone, which actually leads to an increase in the value of calcium in the blood.
- Hyperthyroidism. This condition occurs when the thyroid gland produces and separates very large amounts of thyroid hormones.
- Osteomalacia: This is a condition that weakens bones and can lead to their no longer serious breakdown. It is usually caused by vitamin D deficiency.
High levels of alkaline phosphate can be a symptom of untreated celiac disease.
What does it mean if I have low alkaline phosphatase (ALP)?
Abnormally low alkaline phosphatase (ALP) is less common than elevated alkaline phosphatase (ALP). This may indicate an underlying condition.
- Malnutrition.
- Zinc deficiency.
- Magnesium deficiency.
- Hypothyroidism.
- Rare genetic disorders including hypophosphatasia and Wilson’s disease.
Should I be concerned if I have elevated or low alkaline phosphatase (ALP) test results?
If you have a high or low alkaline phosphata test result, it does not necessarily mean that you have a disease that needs to be treated. Other things can affect the results as well.
- Certain medications, such as birth control pills.
- Your diet.
- Your pregnancy.
- Your age – younger people and babies will have advanced degrees as their bones grow.
- You have AIDS.
- Errors when collecting, transporting, or handling tests.
Before deciding whether you should undergo further testing, your caregiver will consider the following almost every nuance of your health and history
- Your disease status.
- Your current medications.
- How high or low your ALP results are.
- Results from other studies are usually combined with ALP.
- If you feel any signs of the disease.
When should I call my doctor?
Call your own doctor if you have signs of liver damage, such as yellow und, or bone problems, such as bone or joint pain. If liver disease or bone disease has been established with you and you have new or disturbing symptoms, call your care provider.
Do not hesitate to ask your supplier if you have questions about alkaline phosphatase totals.
Note from Cleveland Clinic.
Seeing abnormal test results can be stressful. Know that high or low alkaline phosphatase does not necessarily mean you are cured of an illness; 1 in 20 healthy people have test results that are outside the normal spectrum. Your caregiver can tell you if you should undergo further testing to determine the basis for abnormal values. Don’t be afraid to ask questions of your care provider. They are there to help you.
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