A BCR-ABL1 genetic This test uses a blood or bone marrow monster to look for an abnormal gene named bcr-abl1. This abnormal gene is implicated in certain types of blood cancers. It is found in
- Most people with acquired myelodysplastic leukemia (AML), also called granulocytic leukemia or acquired myelodysplasia.
- Some (all) people with certain forms of acute lymphoblastic leukemia
- Some people with acute myeloid leukemia (AML) seldom have it.
When two separate genes fuse into one gene, an abnormal BCR-ABL1 gene occurs. Genes are short DNA; DNA is made of long, thin strands of material with information that controls how you look and how your body works DNA is packed into the structure of cells called chromosomes, which are the cells that make up your body. Normally, most of your cells have the same set of 23 pairs of chromosomes.
The aberrant BCR-ABL1 gene appears when fragments of chromosomes 9 and 22 cancel space and change. The broken piece of chromosome 9 connects part of the ABL1 gene. It attaches (fuses) with a portion of the BCR gene on chromosome 22. The result is an abnormal BCR-ABL1 merger. The altered chromosome 22 is called the “Philadelphia chromosome,” after the metropolis where scientists discovered it.
Your genes wear special notes to make proteins that can help your cells do their job. However, the abnormal BCR-ABL1 gene has an abnormal protein note. The protein ensures that certain bone marrow cells make a large number of abnormal white blood cells. These abnormal white blood cells are considered leukemic cells. They do not protect you from infections such as healthy white blood cells. They have a good chance to accumulate in the blood and bone marrow and replace healthy blood cells.
There are different types of BCR-ABL1. genetic Testing. They test your blood or bone marrow to see if it is present.
- Abnormal BCR-ABL1 gene.
- A change in chromosome 22 that indicates that you have a Philadelphia chromosome.
The abnormal BCR-ABL1 gene is considered acquired. genetic Alteration. This means that you did not inherit it from your guardian and cannot pass it on to your own children. An acquired configuration occurs after birth, when cells make mistakes when sharing to form new cells, or when DNA is damaged by carcinogens. Configurations occur only in certain types of cells. A genetic configuration is also called a mutation or variation.
Other names: BCR-ABL, BCR-ABL connection, Philadelphia chromosome, B-cell acute lymphoblastic leukemia (B-ALL), acquired myeloid leukemia (AML), T(9; 22), RT-PCR assisted detection of ABL1 transcripts, RT-PCR support quantitative detection of BCR-ABL1 translocation.
What is it used for?
BCR-ABL1 genetic This test is usually used in combination with other studies to diagnose or rule out two specific types of blood cancers
- Chronic myeloenteritis (CML).
- Philadelphia-positive acute lymphoblastic leukemia (PH+ ALL). This is a picture of acute lymphoblastic leukemia with a Philadelphia chromosome.
Certain types of BCR-ABL1 tests are more likely to be used to plan a cure for these blood cancers. Different types of treatments are available. Some medications focus on proteins produced by the BCR-ABL1 gene. In general, these types of drugs cause less damage to normal cells than chemotherapy or irradiation therapy for cancer.
During treatment, the BCR-ABL1 test can be used to see if the cancer is cured. After treatment, testing is often done to see if the cancer returns.
Why is BCR-ABL1 needed? genetic test?
A BCR-ABL1 test may be needed if your doctor believes there is a Leukemie pattern linked to the BCR-ABL1 gene. genetic Diagnostic Testing. Symptoms and signs of these blood cancers include
- Numerous white blood cells on a general blood test (CBC)
- Fatigue
- high fever
- Weight loss
- Nocturnal sweating (sweating during sleep)
- Joint or bone pain
- Pain or full sensation under rib bone on left side.
- Painless lumps in armpits, groin, neck, abdomen.
If you have already been diagnosed with a Leukemie pattern associated with the BCR-ABL1 gene, this test may be needed to
- Help you form an opinion about treatment
- To see how well the treatment works (if the treatment helps, the number of cells with the BCR-ABL1 gene will decrease)
- Check your own health after treatment to see if your blood cancer returns.
What happens with the BCR-ABL1 test? genetic test?
A BCR-ABL1 genetic Blood or bone marrow monsters are usually taken for the test.
During the blood test, a medical professional with a small needle takes blood from a vein in your arm. After the needle goes in, a small amount of blood is collected in a tube or bottle. A small burning sensation is felt as the needle goes in and out. This usually does not take more than 5 minutes.
When undergoing a bone marrow test, the physician usually takes a sample from the back of the thigh. An injection (shot) of a drug that numbs the area is given. Another medication may be given to help you relax or fall asleep.
A bone marrow aspiration consists of two parts, usually performed in sequence.
- In a bone marrow aspiration, the health care provider inserts a delicate needle into the bone and takes a sample of marrow fluid with a syringe attached to the needle.
- For a bone marrow biopsy, the physician inserts a complete needle into the bone and rotates the needle to collect a small sample of bone marrow tissue. Some pressure and brief pain may be felt when the sample is taken.
The procedure takes only a few minutes. The area is then connected. You will be asked to lie down for 15 minutes until bleeding is securely stopped. If you are taking medication to relax or nap, you may need to lie down longer.
Should I prepare for the test?
Usually, no special substances are needed for blood tests. If you are having a bone marrow test, your doctor will indicate if you need to fast (no eating or drinking) a few hours before the test.
Are there any risks associated with the test?
There are not enough risks associated with blood tests. You may experience mild pain and bruising at the site of the needle puncture, but most symptoms disappear quickly.
After the bone marrow test, you may notice that you become stiff or confined to the bed where the sample was taken. This usually disappears after a few days. If you need pain relief, consult your Internet provider.
What do the results mean?
If you have BCR-ABL1 genetic have had a blood cancer diagnostic test, your doctor may use more than one test result to make a diagnosis. Your provider may diagnose acquired myelogenous leukemia (CML) or Philadelphia chromosome-positive acute lymphoblastic leukemia (PH+ all) if the test shows all three of the following
- Abnormal White Blood Cells
- BCR-ABL1 gene
- Philadelphia chromosome
In some cases, a patient may have CML without the Philadelphia chromosome, but this is rare.
If you have had a BCR-ABL1 gene test to see if cancer treatment is working, your doctor will compare the results to previous tests to see if there are any changes over time. How the results are reported will depend on the type of analysis performed. Ask your doctor to write down what the test results mean for your health and healing goals. In short:
- A smaller number of BCR-ABL1 in your sample means that the treatment works to some extent. The results of your study may sketch your response to treatment based on these texts, be insignificant, minimal, sample, large or complete.
- If the number of BCR-ABL1 in your sample increases, this may mean that your treatment is not working. You may need to try another treatment or do more research. An increase in BCR-ABL1 after successful treatment means that your cancer has returned.
Is there anything else I should know about BCR-ABL1? genetic test?
Laboratories use different methods to test the BCR-ABL1 gene and the Philadelphia chromosome. The testing method can affect your results. Therefore, it is imperative that the tests are performed in the same way, usually in the same laboratory. This allows the physician to relate the results over time. Ask your physician if you have any questions about how the test is performed.
MedlinePlus from the State Medical Library provides. & lt; pran & gt; A smaller number of BCR-ABL1 in the sample means that the treatment is working to some extent. A decrease in the number of BCR-ABL1 in the sample means that the treatment is remarkable.
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